{{Rsnum
|rsid=4686799
|Gene=KNG1
|Chromosome=3
|position=186733447
|Orientation=plus
|GMAF=0.27
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=KNG1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 63.4 | 32.1 | 4.5
| HCB | 33.8 | 51.5 | 14.7
| JPT | 32.7 | 52.2 | 15.0
| YRI | 69.0 | 30.3 | 0.7
| ASW | 66.1 | 30.4 | 3.6
| CHB | 33.8 | 51.5 | 14.7
| CHD | 33.9 | 43.1 | 22.9
| GIH | 69.3 | 29.7 | 1.0
| LWK | 56.5 | 37.0 | 6.5
| MEX | 58.6 | 36.2 | 5.2
| MKK | 56.8 | 38.1 | 5.2
| TSI | 58.8 | 36.3 | 4.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs4686799
|Name_s=
|Gene_s=KNG1
|Feature=Intron
|Evidence=PubMed ID:19584173
|Annotation=This study investigated aldosterone response to two antihypertensive drugs with the result that the existence of one or more variants in the KNG1gene influences interindividual variation in aldosterone response. SNP rs4686799 was associated in African-American and European-American responders to the diuretic (p=0.04 and p=0.07 respectively).
|Drugs=hydrochlorothiazide
|Drug Classes=ANTIHYPERTENSIVES
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164920405
}}

{{PMID Auto
|PMID=19330902
|Title=Gender-specific association between the kininogen 1 gene variants and essential hypertension in Chinese Han population.
}}

{{PMID Auto
|PMID=19716087
|Title=Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4686799
|overall_frequency_n=93
|overall_frequency_d=124
|overall_frequency=0.75
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=75
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}