{{Rsnum
|rsid=4712523
|Gene=CDKAL1
|Chromosome=6
|position=20657333
|Orientation=plus
|GMAF=0.4164
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CDKAL1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 42.5 | 47.8 | 9.7
| HCB | 32.8 | 51.8 | 15.3
| JPT | 33.6 | 51.3 | 15.0
| YRI | 12.3 | 39.0 | 48.6
| ASW | 10.5 | 57.9 | 31.6
| CHB | 32.8 | 51.8 | 15.3
| CHD | 38.5 | 42.2 | 19.3
| GIH | 58.4 | 35.6 | 5.9
| LWK | 15.5 | 41.8 | 42.7
| MEX | 46.6 | 43.1 | 10.3
| MKK | 20.5 | 50.0 | 29.5
| TSI | 52.9 | 36.3 | 10.8
| HapMapRevision=28
}}{{PMID|17463248|OA=1
}} associated with [[type-2 diabetes]]

{{PMID Auto GWAS
|PMID=19401414
|Trait=Type 2 diabetes
|Title=Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
|RiskAllele=G
|Pval=7E-20
|OR=1.27
|ORtxt=[1.21-1.33]
|OA=1
}}

{{PMID Auto GWAS
|PMID=19734900
|Trait=Type 2 diabetes and other traits
|Title=Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
|RiskAllele=G
|Pval=2E-12
|OR=1.20
|ORtxt=[1.14-1.26]
}}

{{PMID Auto
|PMID=22437209
|Title=Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese
}}

{{PMID|18426861|OA=1
}} Association analysis of type 2 diabetes Loci in type 1 diabetes.

{{PMID|18852197|OA=1
}} Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

{{PMID|19008344|OA=1
}} Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

{{PMID|19096518|OA=1
}} Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4712523
|overall_frequency_n=62
|overall_frequency_d=128
|overall_frequency=0.484375
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=53
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23334806
|Title=Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}