{{Rsnum
|rsid=471364
|Gene=TTC39B
|Chromosome=9
|position=15289580
|Orientation=minus
|GMAF=0.1028
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TTC39B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 79.6 | 19.5 | 0.9
| HCB | 97.1 | 2.9 | 0.0
| JPT | 93.8 | 6.2 | 0.0
| YRI | 64.6 | 31.3 | 4.1
| ASW | 70.2 | 28.1 | 1.8
| CHB | 97.1 | 2.9 | 0.0
| CHD | 98.2 | 1.8 | 0.0
| GIH | 85.1 | 14.9 | 0.0
| LWK | 67.3 | 29.1 | 3.6
| MEX | 93.1 | 6.9 | 0.0
| MKK | 48.7 | 47.4 | 3.8
| TSI | 75.5 | 23.5 | 1.0
| HapMapRevision=28
}}per the [http://blog.23andme.com/2008/12/08/new-papers-from-nature-genetics-yield-a-bounty-of-cholesterol-snps/ 23andMe blog], the minor allele of this SNP (C) was associated with decreased HDL [[cholesterol]]
 
{| border="1"
|-
!SNP
!Rarer allele
!LDL
!HDL
!TG
|-
| [[rs6544713]] || T || + || ||
|-
| [[rs2650000]] || A || + || ||
|-
| [[rs471364]] || C || || - ||
|-
| [[rs1800961]] || T || || - ||
|-
| [[rs7679]] || C || || - || +
|-
| [[rs2967605]] || T || || - ||
|-
| [[rs2409722]] || T || || || -
|-
| [[rs10903129]] || A || - || - || -
|-
| [[rs6756629]] || A || - || + || -
|-
| [[rs12670798]] || C || + || + || +
|-
| [[rs7395662]] || A || - || + || +
|-
| [[rs174570]] || T || - || - || +
|-
| [[rs2271293]] || A || - || + || -
|-
| [[rs2624265]] || C || || || +
|-
| [[rs2167079]] || T || || + ||
|-
| [[rs9891572]] || T || || + ||
|-
| [[rs4844614]] || T || + || ||
|-
| [[rs5031002]] || G || + || ||
|-
|}

{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=C
|Pval=3E-10
|OR=0.08
|ORtxt=[0.02-0.14] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs471364
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 9p22.3; Reported Gene(s): TTC39B; Risk Allele: rs471364-C); (p-value= 0.0000000003).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740237
}}

{{PMID Auto
|PMID=21738485
|Title=Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs471364
|overall_frequency_n=113
|overall_frequency_d=128
|overall_frequency=0.882812
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=95
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}