{{Rsnum
|rsid=4728142
|Chromosome=7
|position=128933913
|Orientation=plus
|GMAF=0.2961
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 14.2 | 51.3 | 34.5
| HCB | 0.7 | 21.3 | 77.9
| JPT | 1.8 | 14.2 | 84.1
| YRI | 3.4 | 41.5 | 55.1
| ASW | 1.8 | 50.9 | 47.4
| CHB | 0.7 | 21.3 | 77.9
| CHD | 0.0 | 20.2 | 79.8
| GIH | 19.8 | 39.6 | 40.6
| LWK | 1.8 | 33.6 | 64.5
| MEX | 17.2 | 44.8 | 37.9
| MKK | 0.6 | 40.4 | 59.0
| TSI | 25.7 | 52.5 | 21.8
| HapMapRevision=28
}}

{{PMID|18285424|OA=1
}} [[rs4728142]], [[rs3807306]] and a 5 bp insertion-deletion linked [[multiple sclerosis]] in three populations

{{PMID Auto GWAS
|PMID=19838193
|Trait=Systemic lupus erythematosus
|Title=Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
|RiskAllele=A
|Pval=8E-19
|OR=1.43
|ORtxt=[1.32-1.54]
}}

{{omim
|id=612251
|rsnum=4728142
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=A
|Pval=2E-8
|OR=1.0700
|ORtxt=[1.03-1.11]
|OA=1
}}

{{PMID Auto
|PMID=21471993
|Title=Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferon? therapy in multiple sclerosis
}}

{{PMID Auto
|PMID=22440820
|Title=IRF5 polymorphism predicts prognosis in patients with systemic sclerosis
|OA=1
}}

{{PMID|17412832|OA=1
}} Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

{{PMID|19772658|OA=1
}} Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation.

{{PMID|20169177|OA=1
}} Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

{{PMID|20383147|OA=1
}} Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.

{{PMID|20479942|OA=1
}} Genetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.

{{PMID|20691091|OA=1
}} Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data.

{{PMID|20861862}} Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection.

{{PMID|22257839|OA=1
}} A two-marker haplotype in the IRF5 gene is associated with inflammatory bowel disease in a North American cohort.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4728142
|overall_frequency_n=37
|overall_frequency_d=128
|overall_frequency=0.289062
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23372721
|Title=The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis
|OA=1
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Ulcerative colitis
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=A
  |Pval=4E-14
  |OR=1.10
  |ORtxt=[1.066-1.143]
  |OA=1
}}

{{PMID Auto
|PMID=23971939
|Title=IRF5, but not TLR4, DEFEB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population
}}

{{PMID Auto
|PMID=23023776
|Title=European genetic ancestry is associated with a decreased risk of lupus nephritis.
|OA=1
}}

{{PMID Auto
|PMID=25205108
|Title=The IRF5-TNPO3 association with systemic lupus erythematosus (SLE) has two components that other autoimmune disorders variably share
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}