{{Rsnum
|rsid=4730751
|Gene=CAV1
|Chromosome=7
|position=116540796
|Orientation=plus
|GMAF=0.1552
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=CAV1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 7.7 | 38.5 | 53.8
| HCB | 0.0 | 4.4 | 95.6
| JPT | 0.0 | 0.0 | 100.0
| YRI | 12.7 | 34.9 | 52.4
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 4.4 | 95.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs4730751]] is a SNP in the gene for [[CAV1]], a protein that is involved in tissue fibrosis as well as vascular proliferation.

In a study of 785 white kidney transplant donors and their respective recipients, kidneys from [[rs4730751]](A;A) donors were significantly more likely to fail the transplant, compared with those from donors carrying one or two of the more common [[rs4730751]](C) alleles. The hazard ratio was 1.97 (CI: 1.29-3.16, p = 0.002). Overall, the graft failure rate for donor kidneys with the (A;A) genotype was 38.6%, compared with ~22% for donor genotypes (A;C) or (C;C).{{PMID|20371787}}

{{PMID Auto
|PMID=21976276
|Title=eNOS and caveolin-1 gene polymorphisms interaction and intima media thickness: a proof of concept study in ESRD patients.
}}

{{PMID Auto
|PMID=23051628
|Title=Fibrosis-associated single-nucleotide polymorphisms in TGFB1 and CAV1 are not associated with the development of nephrogenic systemic fibrosis
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}