{{Rsnum
|rsid=4731426
|Gene=LEP
|Chromosome=7
|position=128242017
|Orientation=plus
|GMAF=0.4931
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=LEP
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 33.9 | 47.3 | 18.8
| HCB | 64.0 | 31.6 | 4.4
| JPT | 57.1 | 40.2 | 2.7
| YRI | 0.0 | 10.3 | 89.7
| ASW | 1.8 | 24.6 | 73.7
| CHB | 64.0 | 31.6 | 4.4
| CHD | 48.6 | 41.3 | 10.1
| GIH | 31.7 | 53.5 | 14.9
| LWK | 0.0 | 13.0 | 87.0
| MEX | 15.5 | 53.4 | 31.0
| MKK | 2.6 | 39.1 | 58.3
| TSI | 35.3 | 50.0 | 14.7
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs4731426
|Name_s=
|Gene_s=LEP
|Feature=
|Evidence=PubMed ID:18681781
|Annotation=This intronic variant is moderately associated with olanzapine-induced median weight gain and significantly associated with extreme weight gain in schizophrenia subjects from north India.This variant alters the binding of a transcription factor (zinc finger 5) using in silico analysis.
|Drugs=olanzapine
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Curated
|PharmGKB Accession ID=PA162355759
}}

{{PMID Auto
|PMID=19623271
|Title=A Bayesian hierarchical model for analysis of SNP diversity in multilocus, multipopulation samples.
|OA=1
}}

{{PMID Auto
|PMID=21042325
|Title=Phenotypic and genetic variation in leptin as determinants of weight regain.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4731426
|overall_frequency_n=58
|overall_frequency_d=128
|overall_frequency=0.453125
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=41
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}