{{Rsnum
|rsid=4746
|Gene=GLO1
|Chromosome=6
|position=38682852
|Orientation=minus
|GMAF=0.303
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=GLO1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 29.2 | 44.6 | 26.2
| HCB | 77.8 | 22.2 | 0.0
| JPT | 93.2 | 6.8 | 0.0
| YRI | 54.0 | 36.5 | 9.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 77.8 | 22.2 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{omim
|id=138750
|rsnum=4746
|variant=0001
}}

{{ClinVar
|rsid=4746
|Reversed=1
|FwdREF=A
|FwdALT=C
|REF=T
|ALT=G
|RSPOS=38650628
|CHROM=6
|GMAF=0.3027
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05036800000015051f110100
|GENEINFO=GLO1:2739
|GENE_NAME=GLO1
|GENE_ID=2739
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000006.11:g.38650628T>G
|CLNORIGIN=1
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.697; 0.303
|CLNACC=RCV000017412.1
|CLNDBN=Reclassified - variant of unknown significance
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=138750.0001
|COMMON=1
|Disease=Reclassified - variant of unknown significance
}}

{{PMID Auto
|PMID=18518984
|Title=Genome-wide survey of allele-specific splicing in humans.
|OA=1
}}

{{PMID Auto
|PMID=18639233
|Title=An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders.
|OA=1
}}

{{PMID Auto
|PMID=19412133
|Title=Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies.
}}

{{PMID Auto
|PMID=19470168
|Title=NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
|OA=1
}}

{{PMID Auto
|PMID=20180986
|Title=CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.
|OA=1
}}

{{PMID Auto
|PMID=21491613
|Title=Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism.
|OA=1
}}

{{GET Evidence
|gene=GLO1
|aa_change=Glu111Ala
|aa_change_short=E111A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4746
|overall_frequency_n=4392
|overall_frequency_d=10758
|overall_frequency=0.408254
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.003
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23201419
|Title=Identification of glyoxalase 1 polymorphisms associated with enzyme activity.
}}

{{PMID Auto
|PMID=23775136
|Title=C332C genotype of glyoxalase 1 and its association with late diabetic complications.
}}

{{PMID Auto
|PMID=24908234
|Title=Fructosamine 3-kinase and glyoxalase I polymorphisms and their association with soluble RAGE and adhesion molecules in diabetes
}}
{{on chip | 23andMe v3}}