{{Rsnum
|rsid=4750316
|Gene=DKFZp667F0711
|Chromosome=10
|position=6393260
|Orientation=plus
|GMAF=0.2144
|Gene_s=FCGR2C
|Assembly=GRCh37.p10
|GenomeBuild=37.5
|dbSNPBuild=138
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 3.5 | 26.5 | 69.9
| HCB | 2.2 | 25.0 | 72.8
| JPT | 0.0 | 28.6 | 71.4
| YRI | 17.0 | 44.9 | 38.1
| ASW | 14.0 | 52.6 | 33.3
| CHB | 2.2 | 25.0 | 72.8
| CHD | 0.9 | 24.8 | 74.3
| GIH | 4.0 | 36.6 | 59.4
| LWK | 22.7 | 42.7 | 34.5
| MEX | 1.7 | 22.4 | 75.9
| MKK | 25.0 | 50.0 | 25.0
| TSI | 3.9 | 29.4 | 66.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18794853
|Trait=Rheumatoid arthritis
|Title=Common variants at CD40 and other loci confer risk of rheumatoid arthritis
|RiskAllele=G
|Pval=0.0000039999999999999998
|OR=1.14
|ORtxt=[NR]
|OA=1
}}

{{PharmGKB
|RSID=rs4750316
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18794857
|Annotation=This SNP located on chromosomes 10p15 is associated with susceptibility to rheumatoid arthritis in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects.
|Drugs=
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162355652
}}

{{PMID Auto GWAS
|PMID=20453842
|Trait=Rheumatoid arthritis
|Title=Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock
|RiskAllele=G
|Pval=0.000002
|OR=1.15
|ORtxt=[1.09-1.22]
}}

{{PMID|19674979|OA=1
}} Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.

{{PMID|20439292}} Genetic variants in the prediction of rheumatoid arthritis.

{{PMID|20444755|OA=1
}} Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4750316
|overall_frequency_n=99
|overall_frequency_d=128
|overall_frequency=0.773438
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=86
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}