{{Rsnum
|rsid=4762
|Gene=AGT
|Chromosome=1
|position=230710231
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.1038
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=AGT
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 79.8 | 19.3 | 0.9
| HCB | 83.6 | 16.4 | 0.0
| JPT | 85.7 | 14.3 | 0.0
| YRI | 92.4 | 7.6 | 0.0
| ASW | 94.5 | 5.5 | 0.0
| CHB | 83.6 | 16.4 | 0.0
| CHD | 77.8 | 21.3 | 0.9
| GIH | 75.0 | 21.0 | 4.0
| LWK | 90.0 | 10.0 | 0.0
| MEX | 72.7 | 25.5 | 1.8
| MKK | 92.7 | 7.3 | 0.0
| TSI | 78.0 | 19.0 | 3.0
| HapMapRevision=28
}}[[rs4762]], a SNP in the angiotensin II [[AGT]] gene, has been reported to be associated with increased risk for developing [[pre-eclampsia]], based on a study of ~180 [[French-Canadian]] women. The odds ratio associated with the [[rs4762]](T) allele (encoding methionine) was 1.9 (CI:1.2â€“2.9, p=0.0033).{{PMID|14638622}}

Note that [[rs4762]] is commonly referred to in the literature as "T174M" or "Thr174Met"; however, databases now indicate that the amino acid that varies is #207 (not 174), as the protein is currently numbered.

[[rs4762]] was also reported to play the major role in the 2.1 fold increased risk (CI: 1.4-3.4, p=0.0008) for [[pre-eclampsia]] of the [[rs3889728]](A)-[[rs4762]](T)-[[rs699]](C) haplotype.{{PMID|14638622}}

{{ neighbor
| rsid = 699
| distance = 183
}}

{{Venter SNP
|rsid=4762
|allele=A
|frequency=0.075
|uid=1103675360421
|type=heterozygous_SNP
|hugo=AGT
|ensembl gene=ENSG00000135744
|ensembl transcript=ENST00000366667
|sift=AFFECT FUNCTION
|disease=Defects in AGT are associated with susceptibility to essential hypertension (MIM:145500). Hypertension also occurs in 5-7% of all pregnancies where it is a leading cause of maternal, fetal and neonatal morbidity and mortality. Among pregnancy- induced hypertension cases, severe preeclampsia (MIM:189800) is characterized by the development of hypertension and proteinuria after the 20th week of pregnancy and is the most distinctive, life-threatening form.
}}

{{PMID Auto
|PMID=18653189
|Title=Interaction of gender, hypertension, and the angiotensinogen gene haplotypes on the risk of coronary artery disease in a large angiographic cohort
}}

{{PharmGKB
|RSID=rs4762
|Name_s=AGT:Thr174Met; angiotensinogen T174M
|Gene_s=AGT
|Feature=Exon/NonSyn
|Evidence=PubMed ID:11593098
|Annotation=Angiotensinogen polymorphism AGT:Thr174Met was not related to the response to antihypertensives in the SILVHIA study of 86 white hypertensive patients.
|Drugs=atenolol; losartan
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165107176
}}

{{PMID Auto
|PMID=21988197
|Title=Angiotensinogen gene haplotype is associated with the prevalence of Japanese non-alcoholic steatohepatitis
}}

{{PMID Auto
|PMID=22508051
|Title=Renin-Angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions
}}

{{PMID|18196181|OA=1
}} Correction of population stratification in large multi-ethnic association studies.

{{PMID|18279468|OA=1
}} Ten renin-angiotensin system-related gene polymorphisms in maximally treated Canadian Caucasian patients with heart failure.

{{PMID|18637188|OA=1
}} RAS gene polymorphisms, classical risk factors and the advent of coronary artery disease in the Portuguese population.

{{PMID|19105203|OA=1
}} An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

{{PMID|19587357|OA=1
}} A systematic meta-analysis of genetic association studies for diabetic retinopathy.

{{GET Evidence
|gene=AGT
|aa_change=Thr207Met
|aa_change_short=T207M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4762
|overall_frequency_n=1160
|overall_frequency_d=10758
|overall_frequency=0.107827
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=5
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|pph2_score=0.992
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=4
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23594830
|Title=Angiotensinogen Polymorphisms and Post-Transplantation Diabetes Mellitus in Korean Renal Transplant Subjects
}}

{{PMID Auto
|PMID=23716723
|Title=The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population
}}

{{PMID Auto
|PMID=23251296
|Title=Assessment of two missense polymorphisms (rs4762 and rs699) of the angiotensinogen gene and stroke.
|OA=1
}}

{{PMID Auto
|PMID=23648704
|Title=Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue.
}}

{{PMID Auto
|PMID=25020710
|Title=P324Circadian genes in the regulation of lipids in coronary artery disease
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}