{{Rsnum
|rsid=4763655
|Gene=KLRB1
|Chromosome=12
|position=9602982
|Orientation=plus
|GMAF=0.343
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=KLRB1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 12.4 | 41.6 | 46.0
| HCB | 19.3 | 53.3 | 27.4
| JPT | 14.3 | 51.8 | 33.9
| YRI | 0.7 | 27.6 | 71.7
| ASW | 5.3 | 21.1 | 73.7
| CHB | 19.3 | 53.3 | 27.4
| CHD | 22.4 | 49.5 | 28.0
| GIH | 20.0 | 57.0 | 23.0
| LWK | 3.7 | 23.1 | 73.1
| MEX | 24.1 | 44.8 | 31.0
| MKK | 2.6 | 17.3 | 80.1
| TSI | 14.9 | 44.6 | 40.6
| HapMapRevision=28
}}[[rs4763655]] has been reported in a large study to be associated with [[multiple sclerosis]].

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with this allele is 1.10 (CI 1.04-1.17). {{PMID|17660530}}

{{PharmGKB
|RSID=rs4763655
|Name_s=
|Gene_s=KLRB1
|Feature=
|Evidence=PubMed ID:17660530
|Annotation=In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356171
}}

{{PMID Auto
|PMID=21610746
|Title=Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4763655
|overall_frequency_n=42
|overall_frequency_d=128
|overall_frequency=0.328125
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22492128
|Title=Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}