{{Rsnum
|rsid=4774
|Gene=CIITA
|Chromosome=16
|position=10906991
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.2622
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=CIITA
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 10.6 | 37.2 | 52.2
| HCB | 0.0 | 19.0 | 81.0
| JPT | 4.4 | 43.4 | 52.2
| YRI | 6.1 | 39.5 | 54.4
| ASW | 5.4 | 37.5 | 57.1
| CHB | 0.0 | 19.0 | 81.0
| CHD | 0.9 | 17.4 | 81.7
| GIH | 7.9 | 29.7 | 62.4
| LWK | 11.1 | 39.8 | 49.1
| MEX | 32.8 | 46.6 | 20.7
| MKK | 4.5 | 27.6 | 67.9
| TSI | 8.8 | 38.2 | 52.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=19317741
|Title=Autoimmune disease association signals in CIITA and KIAA0350 are not involved in celiac disease susceptibility
}}

{{PMID Auto
|PMID=22272574
|Title=Influence of MHCIITA rs3087456 and rs4774 polymorphisms in the susceptibility to cardiovascular disease of patients with rheumatoid arthritis
}}

{{PMID Auto
|PMID=22461888
|Title=Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis
|OA=1
}}

{{PMID Auto
|PMID=17012290
|Title=Role of the MHC2TA gene in autoimmune diseases.
|OA=1
}}

{{PMID Auto
|PMID=17678724
|Title=Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA.
}}

{{PMID Auto
|PMID=19221398
|Title=Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.
}}

{{PMID Auto
|PMID=19659749
|Title=MHC2TA rs4774C and HHV-6A active replication in multiple sclerosis patients.
}}

{{PMID Auto
|PMID=20211854
|Title=CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=21962857
|Title=Herpesvirus active replication in multiple sclerosis a genetic control?
}}

{{GET Evidence
|gene=CIITA
|aa_change=Gly500Ala
|aa_change_short=G500A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4774
|overall_frequency_n=3013
|overall_frequency_d=10758
|overall_frequency=0.280071
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.004
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23489895
|Title=CIITA rs4774 and rs6498122 polymorphisms are associated with oral lichen planus in Chinese people: a case-control study
}}

{{PMID Auto
|PMID=23777927
|Title=Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}