{{Rsnum
|rsid=4785763
|Gene=AFG3L1
|Chromosome=16
|position=90000528
|Orientation=plus
|GMAF=0.2847
|Gene_s=AFG3L1P
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}[[rs4785763]] is a SNP near the [[MC1R]] gene, which encodes the melanocortin 1 receptor.
 
{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 9.7 | 55.8 | 34.5
| HCB | 3.6 | 38.7 | 57.7
| JPT | 0.0 | 15.9 | 84.1
| YRI | 10.2 | 45.6 | 44.2
| ASW | 12.3 | 35.1 | 52.6
| CHB | 3.6 | 38.7 | 57.7
| CHD | 8.3 | 41.7 | 50.0
| GIH | 12.0 | 35.0 | 53.0
| LWK | 13.6 | 48.2 | 38.2
| MEX | 7.0 | 49.1 | 43.9
| MKK | 19.9 | 58.3 | 21.8
| TSI | 6.9 | 35.3 | 57.8
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19578364
|Trait=Melanoma
|Title=Genome-wide association study identifies three loci associated with melanoma risk
|RiskAllele=A
|Pval=6E-22
|OR=1.36
|ORtxt=[1.28-1.45]
|OA=1
}}
{{PMID|24270849|OA=1
}} [[rs4785763]] was found to be associated with [[melanoma]] based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.
 
{{PMID|18483556|OA=1
}} A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

{{PMID|19340012|OA=1
}} Genome-wide association study of tanning phenotype in a population of European ancestry.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4785763
|overall_frequency_n=81
|overall_frequency_d=120
|overall_frequency=0.675
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=68
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}