{{Rsnum
|rsid=4794067
|Gene=TBX21
|Chromosome=17
|position=47731462
|Orientation=plus
|GMAF=0.2185
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Aspirin Induced Asthma
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TBX21
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 4.4 | 38.9 | 56.6
| HCB | 2.9 | 21.2 | 75.9
| JPT | 0.9 | 14.2 | 85.0
| YRI | 1.4 | 26.5 | 72.1
| ASW | 7.0 | 29.8 | 63.2
| CHB | 2.9 | 21.2 | 75.9
| CHD | 1.9 | 19.4 | 78.7
| GIH | 11.9 | 43.6 | 44.6
| LWK | 4.5 | 30.0 | 65.5
| MEX | 10.3 | 55.2 | 34.5
| MKK | 12.8 | 46.8 | 40.4
| TSI | 14.7 | 33.3 | 52.0
| HapMapRevision=28
}}[[rs4794067(C;C)]] and [[rs4794067(C;T)]] genotypes for the [[TBX21]] gene are calculated to be at 2.15 fold higher risk (CI: 1.26-3.64) for [[aspirin]]-induced [[asthma]] (AIA) compared to [[rs4794067(T;T)]] homozygotes, based on a study of 72 patients vs 640 controls in a study of a Japanese population. {{PMID|15806396}}

Note that in this population, but perhaps not others, linkage disequilibrium exists between this SNP located upstream of the gene, [[rs4794067]], and a common synonymous SNP located in the first exon, [[rs2074190]], with a predictive accuracy of 92%.

On the other hand, [[rs4794067(C;C)]] may greatly decrease the risk of [[lupus]] if [[rs17250932(C;C)]] is also present (at least in Chinese people). {{PMID|20429676}} And those 2 SNPs also reduce the risk of intractable [[Graves' disease]] (at least in Japanese people). {{PMID|22014209}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}