{{Rsnum
|rsid=4796793
|Gene=STAT3
|Chromosome=17
|position=42390192
|Orientation=plus
|GMAF=0.3411
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=STAT3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 57.5 | 33.6 | 8.8
| HCB | 43.8 | 43.1 | 13.1
| JPT | 37.2 | 48.7 | 14.2
| YRI | 15.6 | 47.6 | 36.7
| ASW | 29.8 | 49.1 | 21.1
| CHB | 43.8 | 43.1 | 13.1
| CHD | 34.9 | 53.2 | 11.9
| GIH | 42.4 | 43.4 | 14.1
| LWK | 28.2 | 48.2 | 23.6
| MEX | 60.3 | 39.7 | 0.0
| MKK | 32.9 | 49.7 | 17.4
| TSI | 52.9 | 39.2 | 7.8
| HapMapRevision=28
}}[[rs4796793]], a SNP in the 5' region of the signal transducer and activator 3 [[STAT3]] gene, has been linked in a study of 75 Japanese patients to (successful) response to interferon-alpha immunotherapy for metastatic [[kidney cancer]]. {{PMID|17602083}}

From this paper {{PMID|17602083}}:

"... [[rs4796793]] was the most significant predictor of IFN-alpha response (odds ratio [OR] = 2.73; 95% CI, 1.38 to 5.78). The highest OR was shown in the (C;C) genotype ... compared to the (G;G) + (G;C) genotypes (OR = 8.38, 95% CI, 1.63 to 42.96)."

{{PharmGKB
|RSID=rs4796793
|Name_s=STAT3:(-1697)G>C, 5' upstream of STAT3 -1697bp from exon1
|Gene_s=STAT3
|Feature=
|Evidence=PubMed ID:17602083
|Annotation=Risk or phenotype-associated allele: C Phenotype: Metastatic renal cell carcinoma patients with the CC genotype of STAT3 rs4796793 were more likely to respond to interferon alpha therapy than those with the GC or GG genotype. Study size: 75 (29 responders and 46 non-responders). Study population/ethnicity: Japanese patients with renal cell carcinoma receiving IFN-alpha. Significance metric(s): p = 0.0039, OR = 8.38 Type of association: PD
|Drugs=interferon alfacon-1
|Drug Classes=
|Diseases=Carcinoma, Renal Cell
|Curation Level=Curated
|PharmGKB Accession ID=PA165111403
}}

{{PMID Auto
|PMID=19604093
|Title=Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.
|OA=1
}}

{{PMID Auto
|PMID=21948258
|Title=Association between polymorphisms in the signal transducer and activator of transcription and dilated cardiomyopathy in the Chinese Han population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4796793
|overall_frequency_n=80
|overall_frequency_d=128
|overall_frequency=0.625
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=63
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24781989
|Title=Association between STAT3 gene polymorphisms and ulcerative colitis susceptibility: a case-control study in the Chinese Han population
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
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{{on chip | FTDNA2}}
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{{on chip | HumanOmni1Quad}}