{{Rsnum
|rsid=4818
|Gene=COMT
|Chromosome=22
|position=19963684
|Orientation=plus
|ReferenceAllele=C
|GMAF=0.3232
|Gene_s=COMT,MIR4761
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}Seems to play a role in the brain

{{interesting}}
This is a synonymous change. it does not affect the amino acid.
{{ neighbor
| rsid = 6267
| distance = 944
}}
{{ neighbor
| rsid = 4680
| distance = 64
}}

{{ neighbor
| rsid = 17849308
| distance = 63
}}
{{PMID Auto
|PMID=19367610
|Title=Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients
}}
{{PMID Auto
|PMID=19290789
|Title=Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment
}}
{{PMID Auto
|PMID=19551860
|Title=Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer
}}

{{omim
|desc=CATECHOL-O-METHYLTRANSFERASE; COMT
|id=116790
|rsnum=4818
}}
{{PMID Auto
|PMID=19605537
|Title=Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children
|OA=1
}}
{{PMID Auto
|PMID=19699472
|Title=Tolcapone Effects on Gating, Working Memory, and Mood Interact with the Synonymous Catechol-O-methyltransferase rs4818C/G Polymorphism
}}

{{PharmGKB
|RSID=rs4818
|Name_s=COMT: Leu136Leu
|Gene_s=COMT
|Feature=Exon/Syn
|Evidence=PubMed ID:15537663
|Annotation=On the basis of subjects' pain responsiveness, haplotypes involving rs6269 (A/G), rs4633 (C/T), rs4818 (C/G), and rs4680 (G/A) were designated as low (low pain sensitivity (LPS) haplotype; GCGG), average (average pain sensitivity (APS) haplotype; ATCA), or high (high pain sensitivity (HPS) haplotype; ACCG) pain sensitive.
|Drugs=
|Drug Classes=
|Diseases=Pain
|Curation Level=Curated
|PharmGKB Accession ID=PA164944061
}}

{{PMID Auto
|PMID=20570835
|Title=No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
}}
{{PMID Auto
|PMID=21120493
|Title=Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients
}}

{{PMID Auto
|PMID=21300128
|Title=COMT Val158met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa
}}

{{PMID Auto
|PMID=21940152
|Title=The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
}}

{{PMID Auto
|PMID=22451510
|Title=Catechol-O-Methyltransferase Gene and Executive Function in Children With ADHD
}}

{{PMID Auto
|PMID=22528689
|Title=Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene
}}

{{PMID Auto
|PMID=10709220
|Title=Through the Looking Glass: Differential Noradenergic Modulation of Prefrontal Cortical Function
|OA=1
}}

{{PMID Auto
|PMID=22178088
|Title=Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome
|OA=1
}}
{{PMID Auto
|PMID=15290009
|Title=Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay.
}}

{{PMID Auto
|PMID=16026601
|Title=Decision forest analysis of 61 single nucleotide polymorphisms in a case-control study of esophageal cancer; a novel method.
|OA=1
}}

{{PMID Auto
|PMID=16816940
|Title=Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.
}}

{{PMID Auto
|PMID=16848906
|Title=Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.
|OA=1
}}

{{PMID Auto
|PMID=17135598
|Title=No evidence for a major role of polymorphisms during bupropion treatment.
}}

{{PMID Auto
|PMID=17961261
|Title=Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.
|OA=1
}}

{{PMID Auto
|PMID=17994190
|Title=Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.
}}

{{PMID Auto
|PMID=18037454
|Title=Planning, decision-making and the COMT rs4818 polymorphism in healthy males.
}}

{{PMID Auto
|PMID=18324659
|Title=COMT polymorphisms affecting protein expression are risk factors for endometrial cancer.
}}

{{PMID Auto
|PMID=18574484
|Title=The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18698234
|Title=The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.
}}

{{PMID Auto
|PMID=18802928
|Title=Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.
}}

{{PMID Auto
|PMID=19094200
|Title=Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.
|OA=1
}}

{{PMID Auto
|PMID=19168589
|Title=Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=19365560
|Title=Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{PMID Auto
|PMID=20531207
|Title=The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.
}}

{{PMID Auto
|PMID=20627703
|Title=The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.
}}

{{PMID Auto
|PMID=20842020
|Title=Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.
}}

{{PMID Auto
|PMID=20863768
|Title=Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.
}}

{{PMID Auto
|PMID=21304959
|Title=Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.
|OA=1
}}

{{PMID Auto
|PMID=21423693
|Title=Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.
|OA=1
}}

{{PMID Auto
|PMID=21462137
|Title=[An association study of COMT gene polymorphisms with schizophrenia].
}}

{{PMID Auto
|PMID=21680027
|Title=Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response.
}}

{{PMID Auto
|PMID=22354729
|Title=Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4818
|overall_frequency_n=3505
|overall_frequency_d=10756
|overall_frequency=0.325865
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23872233
|Title=The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample
}}

{{PMID Auto
|PMID=24448899
|Title=Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype
}}

{{PMID Auto
|PMID=22718527
|Title=The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.
}}

{{PMID Auto
|PMID=22890010
|Title=Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.
}}

{{PMID Auto
|PMID=23178897
|Title=The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.
|OA=1
}}

{{PMID Auto
|PMID=24593143
|Title=Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}