{{Rsnum
|rsid=4819756
|Gene=PRODH
|Chromosome=22
|position=18925165
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.2571
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.9 | 53.6 | 28.6
| HCB | 0.0 | 6.6 | 93.4
| JPT | 0.9 | 5.3 | 93.8
| YRI | 0.0 | 4.8 | 95.2
| ASW | 3.5 | 22.8 | 73.7
| CHB | 0.0 | 6.6 | 93.4
| CHD | 0.0 | 8.3 | 91.7
| GIH | 8.9 | 43.6 | 47.5
| LWK | 0.9 | 12.7 | 86.4
| MEX | 10.3 | 48.3 | 41.4
| MKK | 1.9 | 25.0 | 73.1
| TSI | 12.7 | 47.1 | 40.2
| HapMapRevision=28
}}
[http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000252 plos] ({{PMID|18989458|OA=1
}}) - The minor alleles of [[rs4819756]] and [[rs2870983]] were significantly negatively associated with [[schizophrenia]]

{{Venter SNP
|rsid=4819756
|allele=G
|frequency=
|uid=1103691005874
|type=heterozygous_SNP
|hugo=PRODH
|ensembl gene=ENSG00000100033
|ensembl transcript=ENST00000334029
|sift=AFFECT FUNCTION
|disease=Defects in PRODH are the cause of type I hyperprolinaemia (MIM:239500). It is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated in the 22q11 velocardiofacial syndrome.
}}

{{PMID Auto
|PMID=19693005
|Title=Executive function, neural circuitry, and genetic mechanisms in schizophrenia.
|OA=1
}}

{{GET Evidence
|gene=PRODH
|aa_change=Trp77Arg
|aa_change_short=W77R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4819756
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=7
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24853458
|Title=Association of COMT and PRODH gene variants with intelligence quotient (IQ) and executive functions in 22q11.2DS subjects
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}