{{Rsnum
|rsid=4820599
|Gene=GGT1
|Chromosome=22
|position=24594246
|Orientation=plus
|GMAF=0.4155
|Gene_s=C22orf36,GGT1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 53.1 | 39.8 | 7.1
| HCB | 54.0 | 40.1 | 5.8
| JPT | 61.9 | 34.5 | 3.5
| YRI | 1.4 | 23.8 | 74.8
| ASW | 12.3 | 36.8 | 50.9
| CHB | 54.0 | 40.1 | 5.8
| CHD | 53.2 | 40.4 | 6.4
| GIH | 64.4 | 31.7 | 4.0
| LWK | 6.4 | 37.3 | 56.4
| MEX | 19.0 | 58.6 | 22.4
| MKK | 17.4 | 53.5 | 29.0
| TSI | 51.0 | 40.2 | 8.8
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=18940312
|Trait=Plasma levels of liver enzymes
|Title=Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
|RiskAllele=G
|Pval=4E-11
|OR=0.01
|ORtxt=[0.005-0.009] U/L increase
|OA=1
}}

{{omim
|desc=GAMMA GLUTAMYLTRANSFERASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS
|id=612365
|rsnum=4820599
}}

{{PharmGKB
|RSID=rs4820599
|Name_s=
|Gene_s=C22orf36, GGT1
|Feature=
|Evidence=PubMed ID:18940312; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (Initial Sample Size: 7,751 European white individuals; Replication Sample Size: 4,704 European white and Indian Asian individua); (Region: 22q11.23; Reported Gene(s): GGT1, C22orf36; Risk Allele: rs4820599-G); (p-value= 0.00000000004).This variant is associated with Plasma levels of liver enzymes.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740808
}}

{{PMID Auto
|PMID=20484958
|Title=Pooling-Based Genome-Wide Association Study Implicates Gamma-Glutamyltransferase 1 (GGT1) Gene in Pancreatic Carcinogenesis
|OA=1
}}

{{PMID Auto GWAS
|PMID=21909109
|Trait=None
|Title=Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
|RiskAllele=G
|Pval=7E-53
|OR=0.0088
|ORtxt=[0.0076-0.0100] IU/L decrease
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4820599
|overall_frequency_n=60
|overall_frequency_d=128
|overall_frequency=0.46875
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=61
|n_articles=1
|n_articles_annotated=1
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|summary_short=May be associated with the pancreatic cancer risk. 
}}

{{PMID Auto
|PMID=23462328
|Title=Variation in the γ-glutamyltransferase 1 gene and risk of chronic pancreatitis
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}