{{Rsnum
|rsid=4821544
|Gene=NCF4
|Chromosome=22
|position=36862461
|Orientation=plus
|GMAF=0.3214
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NCF4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 8.0 | 42.5 | 49.6
| HCB | 3.7 | 18.4 | 77.9
| JPT | 2.7 | 20.4 | 77.0
| YRI | 43.5 | 48.3 | 8.2
| ASW | 17.5 | 57.9 | 24.6
| CHB | 3.7 | 18.4 | 77.9
| CHD | 1.8 | 13.8 | 84.4
| GIH | 9.0 | 41.0 | 50.0
| LWK | 35.5 | 45.5 | 19.1
| MEX | 5.2 | 31.0 | 63.8
| MKK | 23.7 | 49.4 | 26.9
| TSI | 19.6 | 42.2 | 38.2
| HapMapRevision=28
}}{{Report GE
|PubMed=17435756
|Source=pubmed
|AffyProbeset=SNP_A-2222922
|AffyOrientation=same
|AlleleA=C
|AlleleB=T
|onGW5=1
|rsid=4821544
|ancestral=C
|RiskPopulation=EU
|RiskAllele=C
|CaseFreq=0.4
|ControlFreq=0.33
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.19
|Disease=Crohn's disease
|DiseaseSymbol=CD
|OA=1
}}

A study of 507 CD patients, 475 UC patients and 576 controls from New Zealand Caucasians found that [[rs4821544]], a SNP in the [[NCF4]] gene, was associated specifically with ileal [[Crohn's disease]] but not with other forms of inflammatory bowel disease. The reported odds ratio was 1.425, CI: 1.092-1.859, p=0.009.{{PMID|18580884}}

[[rs4821544]] increases susceptibility to Crohn's disease 1.19 times for carriers of the C allele {{PMID|17435756|OA=1
}}

{{PMID Auto
|PMID=19262523
|Title=rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 1; IBD1
|id=266600
|rsnum=4821544
}}

{{PMID Auto
|PMID=22115380
|Title=Prediction of disease complication occurrence in Crohn's disease using phenotype and genotype parameters at diagnosis
}}

{{PMID Auto GWAS
|PMID=22197932
|Trait=None
|Title=Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
|RiskAllele=C
|Pval=0.000006
|OR=1.0900
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=17068223
|Title=A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}