{{Rsnum
|rsid=4822492
|Gene=ADORA2A
|Chromosome=22
|position=24447626
|Orientation=plus
|GMAF=0.4766
|Gene_s=C22orf45
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 12.3 | 53.8 | 33.8
| HCB | 24.4 | 44.4 | 31.1
| JPT | 18.2 | 47.7 | 34.1
| YRI | 65.1 | 34.9 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 24.4 | 44.4 | 31.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}Variation at this SNP, [[rs4822492]], appears to influence how an individual responds to moderate levels (150mg) of [[caffeine]].{{PMID|18305461|OA=1
}}
{{PMID Auto
|PMID=23535492
|Title=ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus
|OA=1
}}
{{PMID Auto
|PMID=23018769
|Title=A survey of putative anxiety-associated genes in panic disorder patients with and without bladder symptoms
}}