{{Rsnum
|rsid=4825476
|Gene=GRIA3
|Chromosome=X
|position=123307628
|Orientation=plus
|GMAF=0.3392
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GRIA3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 65.5 | 18.6 | 15.9
| HCB | 43.8 | 29.2 | 27.0
| JPT | 49.6 | 26.5 | 23.9
| YRI | 49.0 | 25.2 | 25.9
| ASW | 45.6 | 28.1 | 26.3
| CHB | 43.8 | 29.2 | 27.0
| CHD | 50.9 | 21.3 | 27.8
| GIH | 69.3 | 15.8 | 14.9
| LWK | 36.7 | 29.4 | 33.9
| MEX | 67.2 | 17.2 | 15.5
| MKK | 30.8 | 22.4 | 46.8
| TSI | 73.5 | 12.7 | 13.7
| HapMapRevision=28
}}This SNP, located in an intron of the [[GRIA3]] gene (also known as AMPA3), has been linked in one study to increased thoughts of [[suicide]] in patients taking the anti-depressant drug [[citalopram]]. The increased risk is calculated to be 1.9x. If the individual is also carrying two [[rs2518224(C)]] alleles, i.e. is a [[rs2518224(C;C)]] homozygote, the odds ratio for having suicidal thoughts is increased to ~15x (CI: 3.7 - 60.6). {{PMID|17898344}}

{{PharmGKB
|RSID=rs4825476
|Name_s=
|Gene_s=GRIA3
|Feature=
|Evidence=PubMed ID:17898344
|Annotation=This SNP in the GRIA3 gene was associated with treatment-emergent suicidal ideation during citalopram therapy in a clinically representative cohort of outpatients with major depressive disorder. DNA samples from 1,915 participants were genotyped.
|Drugs=citalopram
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162263538
}}

{{PMID Auto
|PMID=19724244
|Title=Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients.
|OA=1
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4825476
|overall_frequency_n=57
|overall_frequency_d=92
|overall_frequency=0.619565
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=70
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23337130
|Title=Common genetic background in anorexia nervosa and obsessive compulsive disorder: preliminary results from an association study.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}