{{Rsnum
|rsid=4833095
|Gene=TLR1
|Chromosome=4
|position=38798089
|Orientation=plus
|GMAF=0.4711
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=TLR1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.3 | 31.9 | 62.8
| HCB | 47.1 | 41.2 | 11.8
| JPT | 49.1 | 42.0 | 8.9
| YRI | 78.1 | 20.5 | 1.4
| ASW | 61.4 | 36.8 | 1.8
| CHB | 47.1 | 41.2 | 11.8
| CHD | 35.2 | 49.1 | 15.7
| GIH | 19.8 | 54.5 | 25.7
| LWK | 85.5 | 14.5 | 0.0
| MEX | 20.7 | 51.7 | 27.6
| MKK | 69.9 | 27.6 | 2.6
| TSI | 16.7 | 46.1 | 37.3
| HapMapRevision=28
}}{{omim
|id=601194
|rsnum=4833095
|variant=0002
}}
{{PMID Auto
|PMID=21371045
|Title=TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy
}}

{{PMID Auto
|PMID=17554260
|Title=Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18396467
|Title=Genetic variation and haplotype structures of innate immunity genes in eastern India.
|OA=1
}}

{{PMID Auto
|PMID=18635889
|Title=Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.
|OA=1
}}

{{PMID Auto
|PMID=18752252
|Title=Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.
}}

{{PMID Auto
|PMID=19134200
|Title=No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19503599
|Title=The impact of divergence time on the nature of population structure: an example from Iceland.
|OA=1
}}

{{PMID Auto
|PMID=19543401
|Title=Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
|OA=1
}}

{{PMID Auto
|PMID=19567509
|Title=Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
|OA=1
}}

{{PMID Auto
|PMID=20200442
|Title=Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.
|OA=1
}}

{{PMID Auto
|PMID=20459687
|Title=Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
|OA=1
}}

{{PMID Auto
|PMID=20478407
|Title=The toll-like receptor 1 variant S248N influences placental malaria.
}}

{{PMID Auto
|PMID=20617178
|Title=Leprosy and the adaptation of human toll-like receptor 1.
|OA=1
}}

{{PMID Auto
|PMID=21108742
|Title=Toll-like receptor 1 gene polymorphisms in childhood IgA nephropathy: a case-control study in the Korean population.
}}

{{PMID Auto
|PMID=21872627
|Title=Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.
}}

{{GET Evidence
|gene=TLR1
|aa_change=Asn248Ser
|aa_change_short=N248S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4833095
|overall_frequency_n=4670
|overall_frequency_d=10756
|overall_frequency=0.434176
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=62
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.001
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23478521
|Title=Toll-Like Receptor 1 Polymorphisms and Associated Outcomes in Sepsis After Traumatic Injury: A Candidate Gene Association Study
}}

{{ClinVar
|ALT=C
|CAF=0.4711; 0.5289
|CHROM=4
|CLNACC=RCV000008866.1
|CLNALLE=1
|CLNDBN=Leprosy 5
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C2750733:613223
|CLNHGVS=NC_000004.11:g.38799710T>C
|CLNSIG=255
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=601194.0002
|COMMON=1
|Disease=Leprosy 5
|FwdALT=C
|FwdREF=T
|GENEINFO=TLR1:7096
|GENE_ID=7096
|GENE_NAME=TLR1
|REF=T
|RSPOS=38799710
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;S3D;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|VC=SNV
|VP=0x05036800000017051f110101
|WGT=0
|dbSNPBuildID=111
|rsid=4833095
}}

{{PMID Auto
|PMID=23255565
|Title=Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.
|OA=1
}}

{{PMID Auto
|PMID=25028161
|Title=Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease
}}

{{PMID Auto GWAS
  |PMID=24388013
  |Trait=Asthma and hay fever
  |Title=Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
  |RiskAllele=T
  |Pval=5E-12
  |OR=1.20
  |ORtxt=[1.14-1.26]
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}