{{Rsnum
|rsid=4845618
|Gene=IL6R
|Chromosome=1
|position=154427539
|Orientation=plus
|GMAF=0.4761
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=IL6R
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 20.4 | 51.3 | 28.3
| HCB | 23.4 | 54.7 | 21.9
| JPT | 27.4 | 48.7 | 23.9
| YRI | 29.9 | 46.9 | 23.1
| ASW | 29.8 | 47.4 | 22.8
| CHB | 23.4 | 54.7 | 21.9
| CHD | 19.3 | 47.7 | 33.0
| GIH | 24.7 | 59.8 | 15.5
| LWK | 24.8 | 57.8 | 17.4
| MEX | 13.8 | 48.3 | 37.9
| MKK | 39.7 | 41.7 | 18.6
| TSI | 15.7 | 52.9 | 31.4
| HapMapRevision=28
}}
A study of 219 female [[melanoma]] patients and an equal number of controls concluded that 4 linked SNPs within the [[IL6R]] gene were associated with increased [[melanoma]] risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, [[rs4845618]], was 1.72 (CI: 1.04-2.84). The 4 linked SNPs from identified in this study are: [[rs6684439]], [[rs4845618]], [[rs4845622]], and [[rs8192284]].{{PMID|18781131|OA=1
}}

{{PMID Auto
|PMID=17357077
|Title=Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.
|OA=1
}}

{{PMID Auto
|PMID=18276608
|Title=Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.
}}

{{PMID Auto
|PMID=18787421
|Title=Genetic contributions to disparities in preterm birth.
|OA=1
}}

{{PMID Auto
|PMID=18852330
|Title=Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.
|OA=1
}}

{{PMID Auto
|PMID=19249341
|Title=Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}