{{Rsnum
|rsid=4846051
|Gene=MTHFR
|Chromosome=1
|position=11794400
|Orientation=plus
|GMAF=0.07438
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MTHFR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 100.0 | 0.0 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 37.4 | 48.3 | 14.3
| ASW | 54.4 | 36.8 | 8.8
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 48.2 | 44.5 | 7.3
| MEX | 94.8 | 5.2 | 0.0
| MKK | 66.7 | 31.4 | 1.9
| TSI | 99.0 | 1.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs4846051
|Name_s=MTHFR:Phe435PHE; MTHFR:1317T>C
|Gene_s=MTHFR
|Feature=Exon/Syn
|Evidence=PubMed ID:16439441
|Annotation=The C allele of this variant was associated with increased risk of toxicity in African American Rheumatoid Arthritis patients receiving methotrexate.
|Drugs=methotrexate
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA164918207
}}

{{PMID Auto
|PMID=18483346
|Title=Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis.
}}

{{PMID Auto
|PMID=19493349
|Title=118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}