{{Rsnum
|rsid=4870044
|Gene=C6orf97
|Chromosome=6
|position=151580274
|Orientation=plus
|GMAF=0.4564
|Gene_s=CCDC170
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 42.5 | 47.8 | 9.7
| HCB | 3.6 | 38.7 | 57.7
| JPT | 3.5 | 33.6 | 62.8
| YRI | 2.0 | 29.3 | 68.7
| ASW | 15.8 | 50.9 | 33.3
| CHB | 3.6 | 38.7 | 57.7
| CHD | 2.8 | 33.9 | 63.3
| GIH | 32.7 | 51.5 | 15.8
| LWK | 2.7 | 28.2 | 69.1
| MEX | 34.5 | 41.4 | 24.1
| MKK | 9.6 | 37.2 | 53.2
| TSI | 46.1 | 45.1 | 8.8
| HapMapRevision=28
}}

rs4870044 increases susceptibility to Bone mineral density variations, lower for carriers of the T allele {{PMID|18445777}}

{{GWAS Summary
|SNP=rs4870044
|PubMedID=18445777
|Condition=Bone mineral density (spine)
|Gene=ESR1
|Risk Allele=T
|pValue=2.00E-011
|OR=0.11
|95CI=0.08-0.14) SD decreas
}}

{{omim
|desc=BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 11; BMND11
|id=612114
|rsnum=4870044
}}

{{PharmGKB
|RSID=rs4870044
|Name_s=
|Gene_s=C6orf97
|Feature=
|Evidence=PubMed ID:18445777; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple Genetic Loci for Bone Mineral Density and Fractures (Initial Sample Size: 5,861 individuals; Replication Sample Size: 7,925 individuals; Risk Allele: rs4870044-T). This variant is associated with Bone mineral density (spine).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic; Fractures, Bone
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356557
}}

{{PMID Auto
|PMID=22022476
|Title=Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation
|OA=1
}}

{{PMID Auto
|PMID=21646926
|Title=Interactions of osteoporosis candidate genes for age at menarche, age at natural menopause, and maximal height in Han Chinese women
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=19629617
|Title=Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.
|OA=1
}}

{{PMID Auto
|PMID=20072603
|Title=Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4870044
|overall_frequency_n=65
|overall_frequency_d=128
|overall_frequency=0.507812
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=56
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24481879
|Title=Association of ESR1 and C6orf97 gene polymorphism with osteoporosis in postmenopausal women
}}

{{PMID Auto
|PMID=23074152
|Title=Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}