{{Rsnum
|rsid=487989
|Gene=POLA2
|Chromosome=11
|position=65297219
|Orientation=plus
|GMAF=0.123
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=POLA2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 20.7 | 79.3
| HCB | 2.3 | 11.3 | 86.5
| JPT | 0.0 | 9.9 | 90.1
| YRI | 2.9 | 23.6 | 73.6
| ASW | 0.0 | 35.1 | 64.9
| CHB | 2.3 | 11.3 | 86.5
| CHD | 1.0 | 13.5 | 85.6
| GIH | 6.0 | 37.0 | 57.0
| LWK | 3.7 | 15.6 | 80.7
| MEX | 3.5 | 19.3 | 77.2
| MKK | 0.7 | 15.0 | 84.3
| TSI | 4.0 | 17.0 | 79.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs487989
|Name_s=POLA2:2089G>A, G583R
|Gene_s=POLA2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:15224082
|Annotation=Risk or phenotype-associated allele: None. Phenotype: Variants identified in a screen of 13 genes involved in the gemcitabine drug metabolic pathway. For the non-synonymous POLA2:2089G>A (G583R) SNP, the A (583Arg) allele was at frequency 0.18 in both Europeans and Africans. The frequency of GG, GA, AA genotypes were 0.65, 0.34, 0.01 in Europeans, and 0.71, 0.22, 0.07 in Africans, respectively. There was a significant difference between ethnic groups in genotype frequency distribution (p < 0.05). Study size: 184. Study population/ethnicity: Healthy, unrelated blood donors of European (n = 95) and African (n = 89) descent. Significance metric(s): p < 0.05. Type of association: GN.
|Drugs=gemcitabine
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165110719
}}

{{GET Evidence
|gene=POLA2
|aa_change=Gly583Arg
|aa_change_short=G583R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs487989
|overall_frequency_n=1656
|overall_frequency_d=10758
|overall_frequency=0.153932
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=2
|qualitycomment_in_silico=Y
|in_pharmgkb=Y
|pph2_score=0.024
|nblosum100=6
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}