{{Rsnum
|rsid=4894
|Gene=ATF4
|Chromosome=22
|position=39521510
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.2534
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=ATF4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 0.0 | 0.0 | 0.0
| HCB | 0.0 | 0.0 | 0.0
| JPT | 0.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
This SNP is on its own, as well as part of a specific haplotype, associated with an overall higher risk for [[schizophrenia]] in males based on a study of 352 Chinese patients (186 males). The reported odds ratio is 1.78 (CI: 1.19-2.67, p=0.004). {{PMID|18163433}}

{{ neighbor
| rsid = 17001266
| distance = 885
}}

{{GET Evidence
|gene=ATF4
|aa_change=Gln22Pro
|aa_change_short=Q22P
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4894
|overall_frequency_n=3258
|overall_frequency_d=10758
|overall_frequency=0.302844
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.009
|nblosum100=4
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}