{{Rsnum
|rsid=4917
|Gene=AHSG
|Chromosome=3
|position=186619924
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.2943
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=AHSG
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 47.8 | 38.1 | 14.2
| HCB | 53.3 | 40.1 | 6.6
| JPT | 59.3 | 37.2 | 3.5
| YRI | 55.8 | 44.2 | 0.0
| ASW | 50.0 | 39.3 | 10.7
| CHB | 53.3 | 40.1 | 6.6
| CHD | 47.7 | 41.3 | 11.0
| GIH | 73.3 | 23.8 | 3.0
| LWK | 66.4 | 30.0 | 3.6
| MEX | 32.8 | 51.7 | 15.5
| MKK | 78.2 | 19.9 | 1.9
| TSI | 52.0 | 39.2 | 8.8
| HapMapRevision=28
}}

[[rs4917]] is thought to regulate body fat levels and insulin sensitivity. see [[obesity]]

[http://www.apollolipids.org/cms/templates/article.aspx?articleid=5201&zoneid=1 link1] the MET/MET genotype has been previously linked with reduced plasma lipid levels and lower body fat concentrations.

[http://cat.inist.fr/?aModele=afficheN&cpsidt=16815755 link2] Homozygosity for the [[rs2593813]]:G-[[rs4917]]:Met-[[rs4918]]:Ser haplotype conferred an increased risk for leanness (odds ratio=1.90, P=0.027).

{{ neighbor
| rsid = 4918
| distance = 669
}}

{{ neighbor
| rsid = 2518136
| distance = 114
}}

{{PMID Auto
|PMID=19358088
|Title=AHSG Gene Variation is not Associated with Regional Body Fat Distribution - A Magnetic Resonance Study.
}}

{{omim
|desc=ALPHA-2-HS-GLYCOPROTEIN; AHSG
|id=138680
|rsnum=4917
}}

{{PMID Auto
|PMID=20031641
|Title=Association of AHSG Gene Polymorphisms With Fetuin-A Plasma Levels and Cardiovascular Diseases in the EPIC-Potsdam Study
}}

{{PMID Auto
|PMID=21904596
|Title=Genetic Variation of the Human ?-2-Heremans-Schmid Glycoprotein (AHSG) Gene Associated with the Risk of SARS-CoV Infection
|OA=1
}}

{{ClinVar
|rsid=4917
|Reversed=0
|FwdREF=T
|FwdALT=C
|REF=T
|ALT=C
|RSPOS=186337713
|CHROM=3
|GMAF=0.294
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05016800000017051f110100
|GENEINFO=AHSG:197
|GENE_NAME=AHSG
|GENE_ID=197
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.186337713T>C
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.2943; 0.7057
|CLNACC=RCV000017418.1
|CLNDBN=Leanness, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=138680.0001
|COMMON=1
|Disease=Leanness
}}

{{PMID Auto
|PMID=15806395
|Title=AHSG gene variant is associated with leanness among Swedish men.
}}

{{PMID Auto
|PMID=16024912
|Title=Polymorphism of the AHSG gene is associated with increased adipocyte beta2-adrenoceptor function.
}}

{{PMID Auto
|PMID=18316360
|Title=AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects.
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=22024217
|Title=Are AHSG polymorphisms directly associated with coronary atherosclerosis?
}}

{{PMID Auto
|PMID=22101880
|Title=An AHSG gene variant modulates basal metabolic rate and body composition development after a short-time lifestyle intervention.
}}

{{GET Evidence
|gene=AHSG
|aa_change=Met248Thr
|aa_change_short=M248T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4917
|overall_frequency_n=7393
|overall_frequency_d=10758
|overall_frequency=0.68721
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=74
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24265586
|Title=Lack of Association Between Variants within the AHSG , HCRT and NPY2R Genes and Anthropometrical Parameters in Czech Post-Monica Study
|OA=1
}}

{{PMID Auto
|PMID=23801724
|Title=Genetically elevated fetuin-A levels, fasting glucose levels, and risk of type 2 diabetes: the cardiovascular health study.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}