{{Rsnum
|rsid=492602
|Gene=FUT2
|Chromosome=19
|position=48703160
|Orientation=minus
|ReferenceAllele=A
|GMAF=0.3246
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FUT2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 30.1 | 46.0 | 23.9
| HCB | 0.0 | 2.2 | 97.8
| JPT | 0.0 | 0.0 | 100.0
| YRI | 27.2 | 53.7 | 19.0
| ASW | 29.8 | 47.4 | 22.8
| CHB | 0.0 | 2.2 | 97.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 4.0 | 37.6 | 58.4
| LWK | 21.8 | 45.5 | 32.7
| MEX | 8.6 | 55.2 | 36.2
| MKK | 15.4 | 46.8 | 37.8
| TSI | 23.5 | 48.0 | 28.4
| HapMapRevision=28
}}From {{PMID|18776911|OA=1
}}: We identified a strong association (p = 5.36 x 10(-17)) between [[rs492602]] in the [[FUT2]] gene and plasma vitamin B(12) levels in a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) from the Nurses' Health Study. Women homozygous for the [[rs492602]](C) allele (in dbSNP orientation) had higher B(12) levels. This allele is in strong linkage disequilibrium with the FUT2 nonsecretor variant encoding W143X, suggesting a plausible mechanism for altered B(12) absorption and plasma levels.

{{ neighbor
| rsid = 601338
| distance = 257
}}{{GWAS Summary
|SNP=rs492602
|PubMedID=18776911
|Condition=Plasma level of vitamin B12
|Gene=FUT2
|Risk Allele=G
|pValue=5.00E-017
|OR=0.09
|95CI=0.07-0.11) pg/ml decreas
|OA=1
}}

{{omim
|desc=VITAMIN B12 PLASMA LEVEL QUANTITATIVE TRAIT LOCUS 1; B12QTL1
|id=612542
|rsnum=492602
}}

{{omim
|desc=FUCOSYLTRANSFERASE 2; FUT2
|id=182100
|rsnum=492602
}}
{{PMID Auto
|PMID=19744961
|Title=Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway
|OA=1
}}

{{PharmGKB
|RSID=rs492602
|Name_s=
|Gene_s=FUT2
|Feature=
|Evidence=PubMed ID:18776911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Common variants of FUT2 are associated with plasma vitamin B12 levels (Initial Sample Size: 1,658 women; Replication Sample Size: 1,059 women; Risk Allele: rs492602-G). This variant is associated with Plasma level of vitamin B12.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356422
}}

{{PharmGKB
|RSID=rs492602
|Name_s=FUT2: A68A
|Gene_s=FUT2
|Feature=
|Evidence=PubMed ID:18776911
|Annotation=In a genome-wide scan (n = 1,658) and an independent replication sample (n = 1,059) this variant in the FUT2 gene showed a strong association with plasma vitamin B 12 levels. Women homozygous for the rs492602[G] allele had higher B 12 levels.
|Drugs=cyanocobalamin
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162355647
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=G
|Pval=2E-10
|OR=1.2700
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs492602
|overall_frequency_n=5294
|overall_frequency_d=10758
|overall_frequency=0.492099
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=47
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23468552
|Title=Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}