{{Rsnum
|rsid=4934
|Gene=SERPINA3
|Chromosome=14
|position=94614466
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.4362
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SERPINA3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 21.2 | 52.2 | 26.5
| HCB | 38.2 | 52.2 | 9.6
| JPT | 38.9 | 46.0 | 15.0
| YRI | 1.4 | 31.3 | 67.3
| ASW | 1.8 | 50.9 | 47.4
| CHB | 38.2 | 52.2 | 9.6
| CHD | 35.8 | 51.4 | 12.8
| GIH | 18.8 | 57.4 | 23.8
| LWK | 3.6 | 32.7 | 63.6
| MEX | 12.1 | 29.3 | 58.6
| MKK | 9.6 | 35.3 | 55.1
| TSI | 25.5 | 52.9 | 21.6
| HapMapRevision=28
}}

[[rs4934]] increases susceptibility to [[Alzheimer's disease]] 2.56 times for (A;A) homozygotes  {{PMID|10976648}}

{{PMID|18855268}} systolic blood pressure increased with [[rs4934]](A)

{{Venter SNP
|rsid=4934
|allele=A
|frequency=0.492
|uid=1103649133833
|type=heterozygous_SNP
|hugo=SERPINA3
|ensembl gene=ENSG00000196136
|ensembl transcript=ENST00000261981
|sift=TOLERATED
|disease=Defects in SERPINA3 may be a cause of chronic obstructive pulmonary disease (COPD) (MIM:107280).
}}
{{PMID|21067581|OA=1
}} finds no association between [[rs4934]] and pulmonary emphysema

{{PMID Auto
|PMID=19907165
|Title=Polymorphism rs4934 of SERPINA3 and Sporadic Intracranial Aneurysms in the Chinese Population
}}

{{PMID|16617143|OA=1
}} Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.

{{PMID|17054776|OA=1
}} The genetics of chronic obstructive pulmonary disease.

{{PMID|19390575|OA=1
}} Lung cancer susceptibility model based on age, family history and genetic variants.

{{GET Evidence
|gene=SERPINA3
|aa_change=Ala9Thr
|aa_change_short=A9T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4934
|overall_frequency_n=4315
|overall_frequency_d=10758
|overall_frequency=0.401097
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=51
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.514
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}