{{Rsnum
|rsid=4939883
|Chromosome=18
|position=49640844
|Orientation=plus
|GMAF=0.2346
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 64.6 | 32.7 | 2.7
| HCB | 62.0 | 35.0 | 2.9
| JPT | 63.7 | 31.9 | 4.4
| YRI | 23.3 | 50.7 | 26.0
| ASW | 42.1 | 42.1 | 15.8
| CHB | 62.0 | 35.0 | 2.9
| CHD | 65.7 | 31.5 | 2.8
| GIH | 80.2 | 18.8 | 1.0
| LWK | 33.6 | 50.0 | 16.4
| MEX | 91.2 | 8.8 | 0.0
| MKK | 52.6 | 42.3 | 5.1
| TSI | 73.5 | 24.5 | 2.0
| HapMapRevision=28
}}

C allele is associated with 1.87mg/dl increase in [[HDL cholesterol]] (good cholesterol). {{PMID|18193043}}

{{PMID Auto GWAS
|PMID=19060911
|Trait=Cholesterol, total
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=2E-11
|OR=0.07
|ORtxt=[NR] SD increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=T
|Pval=7E-15
|OR=0.14
|ORtxt=[0.10-0.18] SD decrease
|OA=1
}}

{{PharmGKB
|RSID=rs4939883
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 18q21.1; Reported Gene(s): LIPG; Risk Allele: rs4939883-T); (p-value= 0.000000000000007).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740239
}}

{{PharmGKB
|RSID=rs4939883
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 22,562 individuals; Replication Sample Size: NR); (Region: 18q21.1; Reported Gene(s): LIPG; Risk Allele: rs4939883-G); (p-value= 0.00000000002).This variant is associated with Cholesterol, total.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740197
}}

{{PharmGKB
|RSID=rs4939883
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 21,412 individuals; Replication Sample Size: NR); (Region: 18q21.1; Reported Gene(s): LIPG; Risk Allele: rs4939883-G); (p-value= 0.00000000002).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740209
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19185284
|Title=Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19287092
|Title=Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=19802338
|Title=Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20018038
|Title=Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20370913
|Title=Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.
|OA=1
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|OA=1
}}

{{PMID Auto
|PMID=20502693
|Title=Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4939883
|overall_frequency_n=91
|overall_frequency_d=126
|overall_frequency=0.722222
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=76
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}