{{Rsnum
|rsid=4950928
|Gene=CHI3L1
|Chromosome=1
|position=203186754
|Orientation=plus
|GMAF=0.208
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=CHI3L1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 65.5 | 32.8 | 1.7
| HCB | 73.2 | 19.5 | 7.3
| JPT | 68.2 | 29.5 | 2.3
| YRI | 45.6 | 43.9 | 10.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 73.2 | 19.5 | 7.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|17160890|OA=1
}} [[rs4950928]] in [[CHI3L1]] is likely to play roles in the predisposition to [[schizophrenia]].

{{PMID|18767121}} An attempt to repeat the association between [[rs4950928]] and risk for [[schizophrenia]] in an ethnically identical population (Japanese) as well as a new population (Han Chinese) failed to show any significant association.

{{PMID|19568425|OA=1
}} In contrast to previous studies, in this study of 6514 Danish adults the [[rs4950928]](G) allele - rather than the (C) allele - was found to be associated with [[asthma]].

{{ neighbor
| rsid = 10399805
| distance = 116
}}

{{GWAS Summary
|SNP=rs4950928
|PubMedID=18403759
|Condition=YKL-40 levels
|Gene=CHI3L1
|Risk Allele=G
|pValue=1.00E-013
|OR=0.3
|95CI=NR) ng/ml decreas
|OA=1
}}

{{PMID Auto
|PMID=19421404
|Title=Variation in CHI3LI in relation to type 2 diabetes and related quantitative traits
|OA=1
}}

{{omim
|desc=ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 7; ASRT7
|id=611960
|rsnum=4950928
}}

{{omim
|desc=SCHIZOPHRENIA; SCZD
|id=181500
|rsnum=4950928
}}

{{omim
|id=601525
|desc=CHITINASE 3-LIKE 1; CHI3L1
|rsnum=4950928
}}

{{PharmGKB
|RSID=rs4950928
|Name_s=
|Gene_s=CHI3L1
|Feature=
|Evidence=PubMed ID:18403759; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Effect of Variation in CHI31 on Serum YKL-40 Level, Risk of Asthma, and Lung Function (Initial Sample Size: 632 individuals; Replication Sample Size: 206 children; Risk Allele: rs4950928-G). This variant is associated with YKL-40 levels.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356790
}}
{{PMID Auto
|PMID=20051317
|Title=The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis
}}

{{omim
|id=601525
|rsnum=4950928
|variant=0001
}}

{{PMID Auto
|PMID=21714862
|Title=Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL-40 in Danish patients with rheumatoid arthritis and in healthy subjects
|OA=1
}}

{{PMID Auto
|PMID=22103814
|Title=YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C
|OA=1
}}

{{PMID Auto
|PMID=22366530
|Title=A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait
}}

{{PMID Auto
|PMID=22183936
|Title=Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis.
}}

{{PMID Auto
|PMID=19264973
|Title=Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
|OA=1
}}

{{PMID Auto
|PMID=19336781
|Title=Molecular differentiation of schizoaffective disorder from schizophrenia using BDNF haplotypes.
|OA=1
}}

{{PMID Auto
|PMID=20300754
|Title=Lack of evidence for association of two functional SNPs of CHI3L1 gene (HC-gp39) with rheumatoid arthritis.
}}

{{PMID Auto
|PMID=21257319
|Title=Genetic polymorphisms in chitinase 3-like 1 (CHI3L1) are associated with circulating YKL-40 levels, but not with angiographic coronary artery disease in a Chinese population.
}}

{{PMID Auto
|PMID=21530869
|Title=The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4950928
|overall_frequency_n=95
|overall_frequency_d=124
|overall_frequency=0.766129
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=74
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23190377
|Title=Association of CHI3L1 in African-Americans with Prior History of Asthma Exacerbations and Stress
}}

{{PMID Auto
|PMID=23279705
|Title=A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation
|OA=1
}}

{{PMID Auto
|PMID=22989351
|Title=YKL-40-gene polymorphism affects acute cellular rejection and fibrosis progression after transplantation for hepatitis C virus-induced liver disease.
}}

{{PMID Auto
|PMID=23628340
|Title=The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma.
}}

{{PMID Auto
|PMID=25203433
|Title=Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms and Haplotypes with Uterine Cervical Cancer in Taiwanese Women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}