{{Rsnum
|rsid=495366
|Gene=LOC100288077
|Chromosome=11
|position=102824377
|Orientation=plus
|GMAF=0.4279
|Gene_s=COX6CP3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 7.3 | 36.4 | 56.4
| HCB | 35.8 | 48.9 | 15.3
| JPT | 35.7 | 49.1 | 15.2
| YRI | 16.3 | 51.7 | 32.0
| ASW | 14.0 | 36.8 | 49.1
| CHB | 35.8 | 48.9 | 15.3
| CHD | 34.9 | 46.8 | 18.3
| GIH | 31.7 | 47.5 | 20.8
| LWK | 19.3 | 56.0 | 24.8
| MEX | 31.6 | 42.1 | 26.3
| MKK | 16.0 | 51.9 | 32.1
| TSI | 5.0 | 38.0 | 57.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20031604
|Trait=Serum Matrix Metalloproteinase
|Title=Genome-Wide Association Scan Identifies Variants near Matrix Metalloproteinase (MMP) Genes on Chromosome 11q21-22 Strongly Associated With Serum MMP-1 Levels
|RiskAllele=A
|Pval=6E-34
|OR=0.44
|ORtxt=[NR] unit decrease in ln(MMP-1)
|OA=1
}}

{{PharmGKB
|RSID=rs495366
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:20031604
|Annotation=In a GWAS performed on 778 healthy Amish adults, the SNP most strongly associated with circulating MMP1 levels was rs495366, which was related to 17.5% of the association after adjusting for age and sex. Risk or phenotype-associated allele: C allele. Phenotype: associated with higher circulating MMP1 levels. Study size:778. Study population/ethnicity: healthy Amish adults. Significance metric(s): P value: 5.73 x 10(-34). Type of association: CO; GN;
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA165111632
}}

{{PMID Auto
|PMID=17903307
|Title=Framingham Heart Study genome-wide association: results for pulmonary function measures.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs495366
|overall_frequency_n=51
|overall_frequency_d=128
|overall_frequency=0.398438
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22776467
|Title=Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes
}}

{{PMID Auto
|PMID=23497408
|Title=Genetic variants associated with circulating MMP1 levels near matrix metalloproteinase genes on chromosome 11q21-22 in Taiwanese: interaction with obesity
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}