{{Rsnum
|rsid=495828
|Chromosome=9
|position=133279294
|Orientation=plus
|GMAF=0.1887
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 63.1 | 36.0 | 0.9
| HCB | 71.3 | 25.0 | 3.7
| JPT | 54.9 | 43.4 | 1.8
| YRI | 74.1 | 24.5 | 1.4
| ASW | 77.2 | 19.3 | 3.5
| CHB | 71.3 | 25.0 | 3.7
| CHD | 71.6 | 26.6 | 1.8
| GIH | 75.0 | 23.0 | 2.0
| LWK | 75.0 | 23.1 | 1.9
| MEX | 77.6 | 20.7 | 1.7
| MKK | 80.5 | 18.2 | 1.3
| TSI | 63.3 | 28.6 | 8.2
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=22672568
|Trait=Venous thromboembolism
|Title=A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.
|RiskAllele=T
|Pval=3E-16
|OR=1.6500
|ORtxt=None
|OA=1
}}
{{PMID Auto GWAS
|PMID=20139978
|Trait=Hematological and biochemical traits
|Title=Genome-wide association study of hematological and biochemical traits in a Japanese population
|RiskAllele=T
|Pval=6E-10
|OR=0.26
|ORtxt=[NR] % variance
}}
{{PMID Auto GWAS
|PMID=20066004
|Trait=Angiotensin-converting enzyme activity
|Title=A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor
|RiskAllele=A
|Pval=3E-8
|OR=4.90
|ORtxt=[NR] % variance
}}

{{PharmGKB
|RSID=rs495828
|Name_s=Marker for A antigen allele; rs495828 C>A
|Gene_s=ABO
|Feature=
|Evidence=PubMed ID:20066004
|Annotation=Risk or phenotype-associated allele: C Phenotype: Mean angiotensin converting enzyme activity among subjects with the CC genotype at ABO-rs495828 was higher than the CA or AA. Carriage of the A allele is associated with the A blood group antigen. The mean ACE activity of the blood type A subjects was significantly lower than that of the blood type O. Study size: 623 Study population/ethnicity: Multi-Centered Young-Onset Hypertension (AS-YOH) Genetic Study; Han Chinese individuals with Hypertension. Significance metric(s): p = 3.5 &#215; 10&#8722;8 Type of association: PD
|Drugs=
|Drug Classes=ACE INHIBITORS, PLAIN
|Diseases=Hypertension
|Curation Level=Curated
|PharmGKB Accession ID=PA165111694
}}

{{PMID|19648918|OA=1
}} Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

{{PMID|19729612|OA=1
}} Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.

{{PMID|21832968}} Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes.

{{PMID|22258027}} A common variant of the ABO gene protects against hypertension in a Spanish population.

{{PMID Auto
|PMID=23816557
|Title=Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=24803075
|Title=Influence of ABO genotype and phenotype on angiotensin-converting enzyme plasma activity
}}
{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs495828
|overall_frequency_n=18
|overall_frequency_d=128
|overall_frequency=0.140625
|n_genomes=12
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}