{{Rsnum
|rsid=4958847
|Gene=IRGM
|Chromosome=5
|position=150860025
|Orientation=plus
|GMAF=0.3526
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 17.7 | 79.6
| HCB | 40.9 | 43.8 | 15.3
| JPT | 26.5 | 57.5 | 15.9
| YRI | 25.9 | 51.7 | 22.4
| ASW | 24.6 | 43.9 | 31.6
| CHB | 40.9 | 43.8 | 15.3
| CHD | 45.0 | 44.0 | 11.0
| GIH | 3.0 | 33.7 | 63.4
| LWK | 21.1 | 42.2 | 36.7
| MEX | 5.2 | 32.8 | 62.1
| MKK | 13.5 | 46.8 | 39.7
| TSI | 1.0 | 32.4 | 66.7
| HapMapRevision=28
}}
[[rs4958847]] is a SNP in the [[IRGM]] gene.

A study of 507 CD patients, 475 UC patients and 576 controls from New Zealand Caucasians found that [[rs4958847]], a SNP in the [[IRGM]] gene, was associated specifically with ileal [[Crohn's disease]] but not with other forms of inflammatory bowel disease. The reported odds ratio was 1.767, CI: 1.224-2.558, p=0.0022.{{PMID|18580884}}

Another study, including 557 [[Crohn's disease]] (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that [[rs4958847]](A) was associated with CD (p=2.78 x 10(-17), pooled odds ratio 1.31) and UC (p=0.014, pooled odds ratio 1.13).{{PMID|19491842}} 

{{ neighbor
| rsid = 1000113
| distance = 489
}}

{{PMID Auto
|PMID=19174780
|Title=Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 19; IBD19
|id=612278
|rsnum=4958847
}}

{{omim
|desc=IMMUNITY-RELATED GTPase FAMILY, M; IRGM
|id=608212
|rsnum=4958847
}}

{{PMID Auto
|PMID=19953089
|Title=Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
}}

{{PMID Auto
|PMID=22228152
|Title=Mutations in IRGM Are Associated With More Frequent Need for Surgery in Patients With Ileocolonic Crohn's Disease
}}

{{PMID Auto
|PMID=22713085
|Title=IRGM gene polymorphisms and risk of gastric cancer
}}

{{PMID|18438406|OA=1
}} Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

{{PMID|18853133|OA=1
}} Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.

{{PMID|19098858}} Polymorphism of the IRGM gene might predispose to fistulizing behavior in Crohn's disease.

{{PMID|19140132|OA=1
}} Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.

{{PMID|19165925|OA=1
}} Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

{{PMID|19683022}} Lack of association of NKX2-3, IRGM, and ATG16L1 inflammatory bowel disease susceptibility variants with celiac disease.

{{PMID|20106866|OA=1
}} Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.

{{PMID|20395867}} Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?

{{PMID|22065112}} The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.

{{PMID|22508677}} Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the korean population.

{{PMID Auto
|PMID=24232856
|Title=Association between Variants of the Autophagy Related Gene - IRGM and Susceptibility to Crohn's Disease and Ulcerative Colitis: A Meta-Analysis
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}