{{Rsnum
|rsid=4963
|Gene=ADD1
|Chromosome=4
|position=2915035
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.2709
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=ADD1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 66.2 | 32.3 | 1.5
| HCB | 20.5 | 47.7 | 31.8
| JPT | 25.0 | 34.1 | 40.9
| YRI | 69.8 | 30.2 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 20.5 | 47.7 | 31.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs4963]] is in very tight linkage with [[rs4961]], another [[ADD1]] gene SNP, and thus linked to [[hypertension]]. 

The [[rs4963]](C) allele is the more common, predicting (the more common) [[rs4961]](G) allele; the [[rs4963]](G) allele is less common, predicting the [[rs4961]](T) - and risk - allele.

See [[rs4961]] for details.

{{PMID Auto
|PMID=19574959
|Title=Novel genetic variants in the alpha-adducin and guanine nucleotide binding protein beta-polypeptide 3 genes and salt sensitivity of blood pressure.
|OA=1
}}

{{GET Evidence
|gene=ADD1
|aa_change=Ser617Cys
|aa_change_short=S617C
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4963
|overall_frequency_n=1942
|overall_frequency_d=10758
|overall_frequency=0.180517
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}