{{Rsnum
|rsid=4968451
|Gene=BRIP1
|Chromosome=17
|position=61849946
|Orientation=plus
|GMAF=0.2516
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=BRIP1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 72.6 | 26.5 | 0.9
| HCB | 16.1 | 51.8 | 32.1
| JPT | 26.5 | 46.9 | 26.5
| YRI | 89.1 | 10.2 | 0.7
| ASW | 86.0 | 14.0 | 0.0
| CHB | 16.1 | 51.8 | 32.1
| CHD | 20.2 | 46.8 | 33.0
| GIH | 80.2 | 19.8 | 0.0
| LWK | 80.7 | 19.3 | 0.0
| MEX | 69.0 | 27.6 | 3.4
| MKK | 85.3 | 14.7 | 0.0
| TSI | 80.4 | 18.6 | 1.0
| HapMapRevision=28
}}[[rs4968451]], which is in a breast cancer susceptibility gene, was associated with increased risk of [[meningioma]], a common form of [[brain tumor]], in a combination of five studies totaling 631 European patients. The odds ratio was 1.57 (CI: 1.28-1.93, p=.009 after adjusting for multiple testing) for the risk allele, [[rs4988451]](C). Around 30% of Europeans carry one of risk genotypes, i.e. [[rs4968451]](A;C) or (C;C); and perhaps 16% of meningiomas might be associated with this SNP.{{PMID|18270339}}

{{PMID Auto
|PMID=18505952
|Title=Genetic susceptibility to cancer: the role of polymorphisms in candidate genes.
|OA=1
}}

{{PMID Auto
|PMID=19276285
|Title=Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}
{{on chip | NatGeo2}}