{{Rsnum
|rsid=497116
|Gene=CASP12
|Chromosome=11
|position=104892390
|Orientation=minus
|GMAF=0.03994
|Gene_s=CASP12
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 1.5 | 98.5
| JPT | 0.0 | 0.0 | 100.0
| YRI | 2.0 | 27.9 | 70.1
| ASW | 0.0 | 22.8 | 77.2
| CHB | 0.0 | 1.5 | 98.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 5.9 | 94.1
| LWK | 3.6 | 36.4 | 60.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.6 | 14.7 | 84.6
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=22615879
|Title=The loss of functional caspase-12 in europe is a pre-neolithic event.
|OA=1
}}

{{PMID Auto
|PMID=18852891
|Title=Distribution and effects of nonsense polymorphisms in human genes.
|OA=1
}}

{{PMID Auto
|PMID=19200524
|Title=A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs.
|OA=1
}}

{{PMID Auto
|PMID=20210993
|Title=Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.
|OA=1
}}

{{GET Evidence
|gene=CASP12
|aa_change=Arg125Stop
|aa_change_short=R125X
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs497116
|overall_frequency_n=123
|overall_frequency_d=128
|overall_frequency=0.960938
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=106
|n_articles=0
|n_articles_annotated=0
|nblosum100=10
|autoscore=1
|webscore=N
}}

{{ClinVar
|ALT=A
|CAF=0.03994; 0.9601
|CHROM=11
|CLNACC=RCV000002255.1
|CLNALLE=1
|CLNDBN=Sepsis, susceptibility to
|CLNHGVS=NC_000011.9:g.104763117G>A
|CLNSIG=255
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=608633.0001
|COMMON=1
|Disease=Sepsis
|FwdALT=T
|FwdREF=C
|GENEINFO=CASP12:100506742
|GENE_ID=100506742
|GENE_NAME=CASP12
|REF=G
|RSPOS=104763117
|Reversed=1
|SAO=0
|SSR=0
|Tags=RV;PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|VC=SNV
|VP=0x05036800000015051f110100
|WGT=0
|dbSNPBuildID=83
|rsid=497116
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}