{{Rsnum
|rsid=4986761
|Gene=ATM
|Chromosome=11
|position=108254034
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.005051
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ATM
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 0.9 | 99.1
| HCB | 0.0 | 1.5 | 98.5
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 1.5 | 98.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 4.0 | 96.0
| HapMapRevision=28
}}

This SNP, also known as S707P, a variant in the [[ATM]] gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for [[breast cancer]]. {{PMID|17341484}}

For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for [[breast cancer]], refer to the SNPedia [[breast cancer]] entry.

For this particular SNP, the risk (minor) allele is (C).

Another large meta-analysis published in 2011, comprising 26,000+ breast cancer cases and almost 30,000 controls from 23 studies in the Breast Cancer Association Consortium, found average odds ratios of 1.05 for heterozygotes and 1.51 for homozygotes of each of 5 [[ATM]] gene SNPs, of which this is one.{{PMID|20826828|OA=1
}}

{{PMID Auto
|PMID=18701470
|Title=Variants in the ATM gene associated with a reduced risk of contralateral breast cancer.
|OA=1
}}

{{GET Evidence
|gene=ATM
|aa_change=Ser707Pro
|aa_change_short=S707P
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4986761
|overall_frequency_n=88
|overall_frequency_d=10756
|overall_frequency=0.00818148
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=3
|n_articles_annotated=3
|qualityscore_in_silico=0
|qualityscore_case_control=2
|qualitycomment_case_control=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=3
|autoscore=4
|n_web_uneval=10
|variant_evidence=0
|clinical_importance=0
|summary_short=Probably not pathogenic, several papers conclude it is not associated with breast cancer.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}