{{Rsnum
|rsid=4987117
|Gene=BRCA2
|Chromosome=13
|position=32340099
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.01148
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=BRCA2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 94.7 | 5.3 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 98.0 | 2.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 96.6 | 3.4 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 98.0 | 2.0 | 0.0
| HapMapRevision=28
}}

This SNP, a variant in the [[BRCA2]] gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for [[breast cancer]]. {{PMID|17341484}}

For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for [[breast cancer]], refer to the SNPedia [[breast cancer]] entry.

For this particular SNP, the risk (minor) allele is (T).
{{ neighbor
| rsid = 1799954
| distance = 356
}}

{{PMID|20010525}} Association between polymorphisms of the BRCA2 gene and clinical parameters in breast cancer.

{{GET Evidence
|gene=BRCA2
|aa_change=Thr1915Met
|aa_change_short=T1915M
|impact=protective
|qualified_impact=Low clinical importance, Uncertain protective
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4987117
|overall_frequency_n=221
|overall_frequency_d=10758
|overall_frequency=0.0205429
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=1
|n_articles_annotated=1
|qualityscore_case_control=2
|qualitycomment_case_control=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=4
|n_web_uneval=10
|variant_evidence=0
|clinical_importance=0
|summary_short=Serrano-Fernández et al. found this variant to be associated with a modest (OR = 1.61) but significant (P = 0.0007) reduction in breast cancer risk.  
}}

{{ClinVar
|ALT=T
|CAF=0.9885; 0.01148
|CHROM=13
|CLNACC=RCV000034450.1
|CLNALLE=1
|CLNDBN=not provided
|CLNHGVS=NC_000013.10:g.32914236C>T
|CLNSIG=2
|COMMON=1
|Disease=not provided
|FwdALT=T
|FwdREF=C
|GENEINFO=BRCA2:675
|GENE_ID=675
|GENE_NAME=BRCA2
|REF=C
|RSPOS=32914236
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD
|VC=SNV
|VP=0x050168000000150517100101
|WGT=0
|dbSNPBuildID=113
|rsid=4987117
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}