{{Rsnum
|rsid=4987161
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Chromosome=7
|position=99768458
|Gene=CYP3A4
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=CYP3A4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs4987161]], also known as 566T>C, 15615T>C or F189S, is a SNP in the [[CYP3A4]] gene.

The [[rs4987161]](C) allele defines the CYP3A4*17 variant.

{{PharmGKB
|RSID=rs4987161
|Name_s=CYP3A4:F189S; CYP3A4:670 T>C; CYP3A4:189 Phe>Ser; CYP3A4*17
|Gene_s=CYP3A4, CYP3A
|Feature=Exon, NA
|Evidence=Web Resource:http://www.pharmgkb.org/search/annotatedGene/cyp3a4/haplotype.jsp#ImportantHaplotypeInformationforCYP3A4-3
|Annotation=Defining variant for CYP3A4*17, defective in metabolizing the hypertensive drug nifedipine in vitro; exhibited lower turnover numbers than wild-type for testosterone and chlorpyrifos in vitro.
|Drugs=nifedipine
|Drug Classes=
|Diseases=
|Curation Level=In-Depth
|PharmGKB Accession ID=PA161145182
}}

{{PMID Auto
|PMID=23130019
|Title=Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}