{{Rsnum
|rsid=4987188
|Gene=MSH2
|Chromosome=2
|position=47416318
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.009183
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MSH2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 6.3 | 93.7
| HCB | 0.0 | 3.0 | 97.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 2.1 | 97.9
| ASW | 0.0 | 5.4 | 94.6
| CHB | 0.0 | 3.0 | 97.0
| CHD | 0.0 | 0.9 | 99.1
| GIH | 0.0 | 4.0 | 96.0
| LWK | 0.0 | 1.8 | 98.2
| MEX | 0.0 | 6.9 | 93.1
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 3.9 | 96.1
| HapMapRevision=28
}}{{omim
|desc=MSH2 POLYMORPHISM
|id=609309
|rsnum=4987188
|variant=0010
}}

{{ClinVar
|rsid=4987188
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=47643457
|CHROM=2
|GMAF=0.0092
|dbSNPBuildID=113
|SSR=0
|SAO=1
|VP=0x050368000000040517110100
|GENEINFO=MSH2:4436
|GENE_NAME=MSH2
|GENE_ID=4436
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.47643457G>A
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;S3D;SLO;VLD;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9908; 0.009183
|CLNACC=RCV000001832.1; RCV000030257.2; RCV000034561.1
|CLNDBN=MSH2 POLYMORPHISM; Lynch syndrome; not provided
|CLNDSDB=GeneReviews:MedGen:SNOMED_CT
|CLNDSDBID=NBK1211:C0009405:315058005
|CLNSRC=InSiGHT; OMIM Allelic Variant
|CLNSRCID=c.965G>A; 609309.0010
|COMMON=1
|Disease=MSH2 POLYMORPHISM; Lynch syndrome; not provided
}}

{{PMID Auto
|PMID=17119116
|Title=Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.
|OA=1
}}

{{PMID Auto
|PMID=19029193
|Title=Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19389263
|Title=Investigation on the role of nsSNPs in HNPCC genes--a bioinformatics approach.
|OA=1
}}

{{PMID Auto
|PMID=11920
|Title=Isolation and partial characterization of an histidine-rich polypeptide from parotid saliva of the monkey, Macaca nemestrina.
}}

{{PMID Auto
|PMID=10469597
|Title=Mutator phenotypes of common polymorphisms and missense mutations in MSH2.
}}

{{PMID Auto
|PMID=12624141
|Title=Cancer risk in 348 French MSH2 or MLH1 gene carriers.
|OA=1
}}

{{PMID Auto
|PMID=17374836
|Title=MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer.
}}

{{PMID Auto
|PMID=18383312
|Title=Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR).
}}

{{PMID Auto
|PMID=18470917
|Title=Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification.
}}

{{PMID Auto
|PMID=25134804
|Title=Gly322Asp and Asn127Ser single nucleotide polymorphisms (SNPs) of hMSH2 mismatch repair gene and the risk of triple-negative breast cancer in Polish women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}