{{Rsnum
|rsid=4988235
|Gene=MCM6
|Chromosome=2
|position=135851076
|Orientation=minus
|GMAF=0.2332
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MCM6
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 8.8 | 36.3 | 54.9
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 77.2 | 17.5 | 5.3
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 70.3 | 27.7 | 2.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 50.0 | 39.7 | 10.3
| MKK | 0.0 | 0.0 | 0.0
| TSI | 83.3 | 14.7 | 2.0
| HapMapRevision=28
}}Also known as "C/T(-13910)", and located in the [[MCM6]] gene but with influence on the lactase [[LCT]] gene, [[rs4988235]] is one of two SNPs that is associated with the primary haplotype associated with hypolactasia, more commonly known as [[lactose intolerance]] in European Caucasian populations. {{PMID|11788828}}, {{PMID|15114531|OA=1
}}

In these populations, the [[rs4988235(T)]] allele is both the more common allele and the one associated with lactase persistence; individuals who are [[rs4988235(C;C)]] are likely to be lactose intolerant.

In populations of sub-Saharan Africans, though, the [[rs4988235(T)]] allele is so rare that it's unlikely to be predictive of lactase persistence, and other SNPs are predictive instead. [PMID 15106124, PMID 17159977]

* See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601806&a=601806_AllelicVariant0001 OMIM 601806.0001]
{{PMID Auto|PMID=20225268|Title=The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake}}
{{PMID Auto|PMID=20447925|Title=Can lactase persistence genotype be used to reassess the relationship between renal cell carcinoma and milk drinking? Potentials and problems in the application of Mendelian randomization}}
{{PharmGKB
|RSID=rs4988235
|Name_s=C/T -13910
|Gene_s=MCM6
|Feature=
|Evidence=PubMed ID:11788828
|Annotation=Risk or phenotype-associated allele: C .Phenotype: The C allele of this SNP completely associated with lactase non-persistence in nine extended Finnish pedigrees and in 236/236 individuals from four different populations . Study size: 145 family members/9 familes; 236 individuals . Study population/ethnicity: families: Finnish; individuals: Finnish(196), Italian(9), German(9),South Korean(22) .Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Lactose Intolerance
|Curation Level=Curated
|PharmGKB Accession ID=PA165363227
}}

{{PharmGKB
|RSID=rs4988235
|Name_s=C/T -13910
|Gene_s=MCM6
|Feature=
|Evidence=PubMed ID:15114531
|Annotation=Phenotype: This SNP, for which the T allele previously has been shown to be tightly associated with lactase persistance, is part of a haplotype that extends for > 1 Mb and includes rs182549(the A allele is associated with lactase persistance). The haplotype appears to be under strong recent positive selection in European Americans. In European Americans, African Americans and East Asians, the alleles associated with lactase persistance were found to occur at frequencies roughly matching the rates of lactase persistance. Study population/ethnicity: European American, African American, East Asian, Scandinavian. Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Lactose Intolerance
|Curation Level=Curated
|PharmGKB Accession ID=PA165363255
}}

{{omim
|id=601806
|rsnum=4988235
|variant=0001
}}

{{PMID Auto|PMID=22572735|Title=Lactase persistence may have an independent origin in Tibetan populations from Tibet, China
}}

{{PMID|17436249|OA=1
}} Measuring European population stratification with microarray genotype data.

{{PMID|18194137}} Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study.

{{PMID|18462498|OA=1
}} Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.

{{PMID|18602983|OA=1
}} Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1.

{{PMID|18605960}} Genetic testing for adult-type hypolactasia in Italian families.

{{PMID|18797476|OA=1
}} Lactase persistence-related genetic variant: population substructure and health outcomes.

{{PMID|18974842|OA=1
}} Gender differences in genetic risk profiles for cardiovascular disease.

{{PMID|19138442}} Genetic lactase non-persistence, consumption of milk products and intakes of milk nutrients in Finns from childhood to young adulthood.

{{PMID|19265028|OA=1
}} Geographical structure and differential natural selection among North European populations.

{{PMID|19326473|OA=1
}} Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.

{{PMID|19687126|OA=1
}} A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

{{PMID|19943975|OA=1
}} Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms.

{{PMID|20015952|OA=1
}} European lactase persistence genotype shows evidence of association with increase in body mass index.

{{PMID|20031626|OA=1
}} Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.

{{PMID|20109229|OA=1
}} Haplotype allelic classes for detecting ongoing positive selection.

{{PMID|20616999|OA=1
}} Usefulness of Mendelian randomization in observational epidemiology.

{{PMID|21152447}} Adult-type hypolactasia and lactose malabsorption in Poland.

{{PMID|21193851}} Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population.

{{PMID|21235777|OA=1
}} Lactase persistence genotypes and malaria susceptibility in Fulani of Mali.

{{PMID Auto|PMID=22965418|Title=Genetic variation in the lactase gene, dairy product intake and risk for prostate cancer in the European prospective investigation into cancer and nutrition
|OA=1
}}

{{PMID|23252911}} The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children.

{{PMID Auto
|PMID=22948027
|Title=Stronger signal of recent selection for lactase persistence in Maasai than in Europeans.
|OA=1
}}

{{PMID Auto
|PMID=23028602
|Title=Lactase persistence and lipid pathway selection in the Maasai.
|OA=1
}}

{{PMID Auto
|PMID=23029545
|Title=Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population.
|OA=1
}}

{{PMID Auto
|PMID=23479116
|Title=Associations of the lactase persistence allele and lactose intake with body composition among multiethnic children.
|OA=1
}}

{{PMID Auto
|PMID=23647908
|Title=The lactase persistence genotype is associated with body mass index and dairy consumption in the D.E.S.I.R. study.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}