{{Rsnum
|rsid=498872
|Gene=PHLDB1
|Chromosome=11
|position=118606652
|Orientation=minus
|GMAF=0.2328
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=PHLDB1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 49.1 | 39.8 | 11.1
| HCB | 56.9 | 33.6 | 9.5
| JPT | 62.8 | 31.0 | 6.2
| YRI | 87.1 | 12.9 | 0.0
| ASW | 73.2 | 26.8 | 0.0
| CHB | 56.9 | 33.6 | 9.5
| CHD | 38.9 | 50.9 | 10.2
| GIH | 32.7 | 51.5 | 15.8
| LWK | 81.8 | 18.2 | 0.0
| MEX | 59.6 | 31.6 | 8.8
| MKK | 86.5 | 12.2 | 1.3
| TSI | 53.5 | 43.4 | 3.0
| HapMapRevision=28
}}[http://blog.23andme.com/2009/07/06/snpwatch-genetic-variants-near-tumor-suppressor-genes-may-increase-risk-for-brain-and-skin-cancer/ 23andMe blog] [[rs498872]] A 1.18 [[Glioma]]

{{PMID Auto GWAS
|PMID=19578367
|Trait=Glioma
|Title=Genome-wide association study identifies five susceptibility loci for glioma
|RiskAllele=T
|Pval=1E-8
|OR=1.18
|ORtxt=[1.13-1.24]
}}

{{PMID Auto
|PMID=20462933
|Title=Interaction between 5 genetic variants and allergy in glioma risk
}}
{{PMID Auto
|PMID=20847058
|Title=Genetic risk profiles identify different molecular etiologies for glioma
|OA=1
}}
{{PMID Auto
|PMID=20211558
|Title=Genetic advances in glioma: susceptibility genes and networks
|OA=1
}}

{{PMID Auto
|PMID=21350045
|Title=Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population
}}

{{PMID Auto GWAS
|PMID=21531791
|Trait=None
|Title=Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|RiskAllele=
|Pval=5E-11
|OR=1.2200
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=17846999
|Title=A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20212223
|Title=New insights into susceptibility to glioma.
}}

{{PMID Auto
|PMID=21825990
|Title=Genetic causes of glioma: new leads in the labyrinth.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs498872
|overall_frequency_n=99
|overall_frequency_d=128
|overall_frequency=0.773438
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=91
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23361564
|Title=Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology
|OA=1
}}

{{PMID Auto
|PMID=23161787
|Title=Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies
|OA=1
}}

{{PMID Auto
|PMID=23733245
|Title=Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
}}

{{PMID Auto
|PMID=24935770
|Title=The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis
}}

{{PMID Auto
|PMID=25165198
|Title=Mutation-based molecular glioma classification: prevalence and association with germline risk snps
}}

{{PMID Auto
|PMID=25182002
|Title=Assessment of Glioma Risk Associated with an Inherited Variant at Chromosome 11q23
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}