{{Rsnum
|rsid=4994
|Gene=ADRB3
|Chromosome=8
|position=37966280
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.1001
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ADRB3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.9 | 15.9 | 83.2
| HCB | 0.0 | 24.8 | 75.2
| JPT | 5.4 | 27.7 | 67.0
| YRI | 1.4 | 10.2 | 88.4
| ASW | 0.0 | 14.0 | 86.0
| CHB | 0.0 | 24.8 | 75.2
| CHD | 2.8 | 23.9 | 73.4
| GIH | 1.0 | 24.8 | 74.3
| LWK | 0.0 | 17.3 | 82.7
| MEX | 1.7 | 20.7 | 77.6
| MKK | 1.9 | 22.4 | 75.6
| TSI | 0.0 | 7.8 | 92.2
| HapMapRevision=28
}}[[rs4994]], also known as Trp64Arg or as the Arg64 variant, is a SNP in the [[ADRB3]] gene. The [[rs4994]](C) allele encodes the variant arginine.

In a study of 600+ women initially referred for coronary angiography and then followed for 6 years, during which time 115 experienced a heart problem, [[rs4994]](C) individuals were calculated to be at higher risk (adjusted hazard ratio 2.10, CI: 1.05-4.24). This risk was due to subtle increases in risk for all of the individual endpoints, and was only seen in women without obstructive coronary artery disease.{{PMID|18331634|OA=1
}}

{{omim
|desc=OBESITY, SUSCEPTIBILITY TO
|id=109691
|rsnum=4994
|variant=0001
}}

{{PMID Auto
|PMID=19553224
|Title=Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance
}}
{{PMID Auto
|PMID=19565482
|Title=Association of adrenergic receptor gene polymorphisms with different [[fibromyalgia]] syndrome domains
}}

{{PharmGKB
|RSID=rs4994
|Name_s=ADRB3:Trp64Arg
|Gene_s=ADRB3
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19193342
|Annotation=Arg in position 64 associated with olanzapine-induced weight gain
|Drugs=olanzapine
|Drug Classes=
|Diseases=Weight gain
|Curation Level=Curated
|PharmGKB Accession ID=PA164889041
}}

{{PMID Auto
|PMID=20503258
|Title=Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City
}}

{{PMID Auto
|PMID=21285172
|Title=Positive Correlation Between Beta-3-Adrenergic Receptor (ADRB3) Gene and Gout in a Chinese Male Population
}}

{{PMID Auto
|PMID=22550477
|Title=ADRB3 Polymorphism Associated with BMI Gain in Japanese Men
|OA=1
}}

{{ClinVar
|rsid=4994
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=37823798
|CHROM=8
|GMAF=0.0998
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05037800000015051f110100
|GENEINFO=ADRB3:155
|GENE_NAME=ADRB3
|GENE_ID=155
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000008.10:g.37823798A>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=109691.0001
|CLNSIG=255
|CLNCUI=C0028754
|CLNDBN=Obesity
|Disease=Obesity
|CLNACC=RCV000033197.1
|Tags=RV;PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.8999; 0.1001
|CLNDSDB=MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C0028754:601665:71529:414916001
|COMMON=1
}}

{{PMID Auto
|PMID=17512307
|Title=Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations.
|OA=1
}}

{{PMID Auto
|PMID=17825092
|Title=Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography.
|OA=1
}}

{{PMID Auto
|PMID=18304332
|Title=No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.
|OA=1
}}

{{PMID Auto
|PMID=18426866
|Title=Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18611262
|Title=Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.
|OA=1
}}

{{PMID Auto
|PMID=18936436
|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=19587357
|Title=A systematic meta-analysis of genetic association studies for diabetic retinopathy.
|OA=1
}}

{{PMID Auto
|PMID=20028936
|Title=Are elite endurance athletes genetically predisposed to lower disease risk?
}}

{{PMID Auto
|PMID=20078877
|Title=Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.
|OA=1
}}

{{PMID Auto
|PMID=22391941
|Title=Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.
}}

{{GET Evidence
|gene=ADRB3
|aa_change=Trp64Arg
|aa_change_short=W64R
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs4994
|overall_frequency_n=909
|overall_frequency_d=10748
|overall_frequency=0.0845739
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=11
|n_articles=1
|n_articles_annotated=1
|in_omim=Y
|in_pharmgkb=Y
|nblosum100=7
|autoscore=2
|webscore=N
}}

[[Response to Diet and Exercise]]

{{PMID Auto
|PMID=22775001
|Title=Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients
|OA=1
}}

{{PMID Auto
|PMID=24201118
|Title=Significant role of ADRB3 rs4994 towards the development of coronary artery disease
}}

{{PMID Auto
|PMID=22858200
|Title=Angiotensinogen gene polymorphisms and food-intake behavior in young, normal female subjects in Japan.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}