{{Rsnum
|rsid=5020278
|Gene=OR7D4
|Chromosome=19
|position=9214440
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.1566
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=OR7D4
}}[[rs5020278]], a SNP in the [[OR7DR]] olfactory receptor gene, is associated with how individuals perceive the [[smell]] of a testosterone-derived steroid, androstenone. This SNP is also known as T133M as it causes a change at amino acid 133 of the [[OR7D4]] protein from threonine to methionine.

In the orientation reported for this SNP in dbSNP, most individuals (~75%) are homozygous for [[rs5020278]](G), and perceive this steroid as smelling either strongly sweaty or like urine. Individuals with one or two copies of [[rs5020278]](A) perceive the smell to be both weaker, and more sweet, with some likening it to vanilla or honey.{{PMID|17873857}}

{{GET Evidence
|gene=OR7D4
|aa_change=Thr133Met
|aa_change_short=T133M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5020278
|overall_frequency_n=1602
|overall_frequency_d=10758
|overall_frequency=0.148912
|n_genomes=8
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.003
|nblosum100=2
|autoscore=0
|webscore=N
}}
{{on chip | 23andMe v3}}
{{on chip | HumanOmni1Quad}}