{{Rsnum
|rsid=5030952
|Gene=CAPN10
|Chromosome=2
|position=240603286
|Orientation=plus
|GMAF=0.2378
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{omim
|id=605286
|desc=CALPAIN 10; CAPN10
|rsnum=5030952
}}

{{PMID Auto
|PMID=19752882
|Title=Association of calpain-10 gene polymorphism and posttransplant diabetes mellitus in kidney transplant patients medicated with tacrolimus
}}

{{PharmGKB
|RSID=rs5030952
|Name_s=SNP-63: rs5030952:C>T
|Gene_s=CAPN10
|Feature=
|Evidence=PubMed ID:19752882
|Annotation=Risk or phenotype-associated allele: T. Phenotype: Carrying the T allele of SNP-63: rs5030952 was associated with increased risk of posttransplant diabetes in response to tacrolimus. Study size: 214. Study population/ethnicity: Patients who had undergone organ transplantation (kidney) and were treated with tacrolimus. Significance metric(s): OR = 2.45; p = 0.023. Type of association: CO.
|Drugs=tacrolimus
|Drug Classes=
|Diseases=Diabetes Mellitus; Organ Transplantation; Transplantation
|Curation Level=Curated
|PharmGKB Accession ID=PA165109599
}}

{{PMID Auto
|PMID=20470430
|Title=Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study
|OA=1
}}

{{omim
|id=605286
|rsnum=5030952
|variant=0003
}}

{{PMID Auto
|PMID=22384174
|Title=Association of CAPN10 SNPs and Haplotypes with Polycystic Ovary Syndrome among South Indian Women
|OA=1
}}

{{PMID Auto
|PMID=14730479
|Title=Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=19193380
|Title=Replication of calpain-10 genetic association with carotid intima-media thickness.
|OA=1
}}

{{PMID Auto
|PMID=19387820
|Title=Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.
|OA=1
}}

{{PMID Auto
|PMID=20119856
|Title=Haplotype association of calpain 10 gene variants with type 2 diabetes mellitus in an Irish sample.
}}

{{PMID Auto
|PMID=20667559
|Title=Association of calpain 10 gene polymorphisms with type 2 diabetes mellitus in Southern Indians.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5030952
|overall_frequency_n=26
|overall_frequency_d=126
|overall_frequency=0.206349
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24612564
|Title=Association of IRS-1, CAPN10 and PPARG gene polymorphisms with T2DM in the high risk population of Hyderabad, India
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}