{{Rsnum
|rsid=5051
|Gene=AGT
|Chromosome=1
|position=230714126
|Orientation=plus
|GMAF=0.3356
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=AGT
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 39.8 | 40.7 | 19.5
| HCB | 5.8 | 30.7 | 63.5
| JPT | 0.9 | 31.9 | 67.3
| YRI | 0.0 | 11.6 | 88.4
| ASW | 5.3 | 33.3 | 61.4
| CHB | 5.8 | 30.7 | 63.5
| CHD | 6.4 | 32.1 | 61.5
| GIH | 13.9 | 49.5 | 36.6
| LWK | 0.9 | 18.2 | 80.9
| MEX | 6.9 | 50.0 | 43.1
| MKK | 1.3 | 26.3 | 72.4
| TSI | 32.4 | 48.0 | 19.6
| HapMapRevision=28
}}[[rs5051]] is a SNP in the promoter of the angiotensin [[AGT]] gene, and presumably due to it's tight linkage with [[rs699]], the [[rs5051]](T) allele - as oriented to the dbSNP entry, not as published - has been associated with increased risk for [[hypertension]] and complications thereof. [[rs699]](T) is associated with higher plasma angiotensinogen levels, and therefore the increased risk of essential hypertension. The frequency of the [[rs699]](T) allele is also generally higher in African populations compared to Caucasian populations, correlating to the higher incidence of [[hypertension]] in African population.{{PMID|15077204|OA=1
}}

[[rs5051]] is also known as "A-6G". For more details, see [[rs699]].

[[rs5051]](T;T) homozygotes have been reported to be at increased risk for [[Crohn's disease]], as based on one cohort of ~350 Australian patients. The odds ratio was 2.38 (CI: 1.32-4.32, p=0.007). The authors suggest that association of an [[AGT]] SNP with [[Crohn's disease]] supports a potential role for angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the treatment of [[Crohn's disease]].{{PMID|17047091|OA=1
}}

{{PMID Auto
|PMID=22508051
|Title=Renin-Angiotensin-aldosterone system gene polymorphisms and coronary artery disease: detection of gene-gene and gene-environment interactions
}}

{{PMID|16286570}} A population association study of angiotensinogen polymorphisms and haplotypes with left ventricular phenotypes.

{{PMID|18076107|OA=1
}} Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.

{{PMID|19105203|OA=1
}} An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

{{PMID|20808897|OA=1
}} Disease-associated mutations that alter the RNA structural ensemble.

{{PMID|22388798|OA=1
}} Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.

{{PMID Auto
|PMID=23716723
|Title=The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population
}}

{{PMID Auto
|PMID=21859746
|Title=Genetic and BMI risks for predicting blood pressure in three generations of West African Dogon women.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}