{{Rsnum
|rsid=5063
|Gene=NPPA
|Chromosome=1
|position=11847591
|Orientation=minus
|GMAF=0.05739
|Gene_s=NPPA,NPPA-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 10.6 | 88.5
| HCB | 0.7 | 15.3 | 83.9
| JPT | 0.0 | 19.5 | 80.5
| YRI | 0.0 | 8.2 | 91.8
| ASW | 0.0 | 7.0 | 93.0
| CHB | 0.7 | 15.3 | 83.9
| CHD | 0.9 | 17.4 | 81.7
| GIH | 1.0 | 18.8 | 80.2
| LWK | 0.0 | 12.7 | 87.3
| MEX | 0.0 | 8.6 | 91.4
| MKK | 0.0 | 7.7 | 92.3
| TSI | 0.0 | 2.9 | 97.1
| HapMapRevision=28
}}{{PMID Auto
|PMID=20064500
|Title=Identification of NPPA variants associated with Atrial Fibrillation in a Chinese GeneID Population
}}

{{PMID Auto
|PMID=20543198
|Title=Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation
|OA=1
}}

{{PMID Auto
|PMID=16368448
|Title=Association between human atrial natriuretic peptide Val7Met polymorphism and baseline blood pressure, plasma trough irbesartan concentrations, and the antihypertensive efficacy of irbesartan in rural Chinese patients with essential hypertension.
}}

{{PMID Auto
|PMID=16642433
|Title=Polymorphism in maternal LRP8 gene is associated with fetal growth.
|OA=1
}}

{{PMID Auto
|PMID=17984371
|Title=Natriuretic peptide precursor a gene polymorphisms and risk of blood pressure progression and incident hypertension.
}}

{{PMID Auto
|PMID=18294255
|Title=A polymorphism in the NPPA gene associates with asthma.
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19219041
|Title=Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.
|OA=1
}}

{{PMID Auto
|PMID=19326473
|Title=Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.
|OA=1
}}

{{PMID Auto
|PMID=19330901
|Title=Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19559392
|Title=A candidate gene association study of 77 polymorphisms in migraine.
|OA=1
}}

{{PMID Auto
|PMID=19944404
|Title=Genomic dissection of population substructure of Han Chinese and its implication in association studies.
|OA=1
}}

{{PMID Auto
|PMID=20031578
|Title=Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=21273288
|Title=Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
|OA=1
}}

{{GET Evidence
|gene=NPPA
|aa_change=Val32Met
|aa_change_short=V32M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs5063
|overall_frequency_n=556
|overall_frequency_d=10758
|overall_frequency=0.0516825
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=1
|n_web_uneval=10
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}