{{Rsnum
|rsid=5068
|Gene=NPPA-AS1
|Chromosome=1
|position=11845917
|Orientation=plus
|GMAF=0.03076
|Gene_s=NPPA,NPPA-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 13.3 | 86.7
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 5.4 | 94.6
| ASW | 0.0 | 1.8 | 98.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 6.9 | 93.1
| LWK | 0.9 | 5.5 | 93.6
| MEX | 0.0 | 0.0 | 0.0
| MKK | 2.6 | 11.5 | 85.9
| TSI | 1.0 | 7.8 | 91.2
| HapMapRevision=28
}}

A study of ~15,000 Europeans found that increased circulating natriuretic peptide and thus lower [[blood pressure]] and [[hypertension]] were associated with SNPs [[rs17376328]](A), [[rs5068]], [[rs198358]](C), [[rs632793]](G)
{{PMID|19219041|OA=1
}}[http://blog.23andme.com/2009/02/17/snpwatch-common-genetic-variations-may-keep-blood-pressure-down/ 23andMe blog]

{{PMID Auto
|PMID=22496669
|Title=A Genome-Wide Screen for Genetic Variants That Modify the Recruitment of REST to Its Target Genes
|OA=1
}}

{{PMID Auto
|PMID=19439027
|Title=Dissecting complex traits: recent advances in hypertension genomics.
|OA=1
}}

{{PMID Auto
|PMID=20407391
|Title=Association of common variants in NPPA and NPPB with blood pressure does not translate into kidney damage in a general population study.
}}

{{PMID Auto
|PMID=21273288
|Title=Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.
|OA=1
}}

{{PMID Auto
|PMID=21276798
|Title=Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes.
}}

{{PMID Auto
|PMID=21798427
|Title=A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community.
|OA=1
}}

{{PMID Auto
|PMID=22504314
|Title=Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.
|OA=1
}}

{{PMID Auto
|PMID=23799939
|Title=A genetic variant of the atrial natriuretic peptide gene is associated with left ventricular hypertrophy in a non-diabetic population -- the Malmo preventive project study
|OA=1
}}

{{PMID Auto
|PMID=23315043
|Title=Common genetic variants of the natriuretic peptide gene locus are not associated with heart failure risk in participants in the EPIC-Norfolk study
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}