{{Rsnum
|rsid=507666
|Gene=ABO
|Chromosome=9
|position=133273983
|Orientation=plus
|GMAF=0.1644
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=ABO
}}{{GWAS Summary
|SNP=rs507666
|PubMedID=18604267
|Condition=Soluble ICAM-1
|Gene=ABO
|Risk Allele=G
|pValue=5.00E-029
|OR=17.73
|95CI=NR) umol/L decreas
|OA=1
}}

{{PharmGKB
|RSID=rs507666
|Name_s=
|Gene_s=ABO
|Feature=
|Evidence=PubMed ID:18604267; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women (Initial Sample Size: 4,570 women; Replication Sample Size: 2,008 women; Risk Allele: rs507666-G). This variant is associated with Soluble ICAM-1.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Malaria; Myocardial Infarction; Stroke
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356565
}}

{{PMID Auto GWAS
|PMID=21533024
|Trait=None
|Title=Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.
|RiskAllele=A
|Pval=3E-91
|OR=17.3000
|ORtxt=[NR] ng/mL decrease
|OA=1
}}[[ABO blood group]]

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19648918
|Title=Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
|OA=1
}}

[[rs507666]], at the [[ABO]] (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.{{PMID|   18604267}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs507666
|overall_frequency_n=17
|overall_frequency_d=128
|overall_frequency=0.132812
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=24386095
  |Trait=Lipid traits
  |Title=A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
  |RiskAllele=A
  |Pval=4E-11
  |OR=.02
  |ORtxt=[0.0091-0.0209] mmol/L increase
  }}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}